Evidence map›Paper›PMID 38770886›Full record

ReviewJournal of cellular and molecular medicine2024

The hope, hype and obstacles surrounding cell therapy.

Cezary Tręda, Aneta Włodarczyk, Piotr Rieske

Abstract readReview
In one paragraph

Review in Journal of cellular and molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. The hope, hype and obstacles surrounding cell therapy.Journal of cellular and molecular medicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cezary TrędaDepartment of Tumor Biology, Medical University of Lodz, Lodz, Poland.ORCID 0000-0001-5348-3155
Aneta WłodarczykDepartment of Tumor Biology, Medical University of Lodz, Lodz, Poland.ORCID 0000-0002-9390-5639
Piotr RieskeDepartment of Tumor Biology, Medical University of Lodz, Lodz, Poland.

Funding

Medical Research Agency 2020/ABM/04/00002-00
6 · The paper itself

Abstract

Cell therapy offers hope, but it also presents challenges, most particularly the limited ability of human organs and tissues to regenerate. Since many diseases are associated with irreversible pathophysiological or traumatic changes, stem cells and their derivatives are unable to secure healing. Although regenerative medicine offers chances for improvements in many diseases, such as type one diabetes and Parkinson's disease, it cannot eliminate the primary cause of many of them. While successes can be expected for diseases such as sickle cell disease, this is not the case for hereditary diseases with varied mutation types or for ciliopathies, which start in embryogenesis. In this complicated medical environment, synthetic biology offers some solutions, but their implementation will take many years. Still, positive examples such as CAR-T therapy offer hope.

Indexed as

Cell- and Tissue-Based TherapyRegenerative MedicineAnimalsHumansCAR‐Tcell therapystem cellssynthetic biology

Identifiers

PMID38770886
PMCPMC11107145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.