Evidence map›Paper›PMID 38770228›Full record

ArticleAging research (Hong Kong, China)2023

Multiple lineage-specific epigenetic landscapes at the antigen receptor loci.

Xiang Qiu, Guanxiang Liang, Weiqiang Zhou, Ranjan Sen, Michael L Atchison

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging research (Hong Kong, China), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiang QiuDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Guanxiang LiangDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Weiqiang ZhouDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
Ranjan SenLaboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, Maryland 21224, USA.
Michael L AtchisonDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Funding

Control of B cell Development by YY1R01AI079002 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ATCHISON, MICHAEL LEE · 2010 to 2020
$4.3M
Mechanisms of lineage plasticity revealed by YY1 deficiency.R01AI162879 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ATCHISON, MICHAEL LEE · 2021 to 2025
$2.5M
YY1-dependent chromatin structure stabilization of B lineage commitmentR01AI155540 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ATCHISON, MICHAEL LEE · 2021 to 2025
$2.5M
NIAID NIH HHS R01 AI079002NIAID NIH HHS R01 AI155540NIAID NIH HHS R01 AI162879
6 · The paper itself

Abstract

Antigen receptors (AgRs) expressed on B and T cells provide the adaptive immune system with ability to detect numerous foreign antigens. Epigenetic features of B cell receptor (BCR) and T cell receptor (TCR) genes were previously studied in lymphocytes, but little is known about their epigenetic features in other cells. Here, we explored histone modifications and transcription markers at the BCR and TCR loci in lymphocytes (pro-B, DP T cells, and mature CD4

Indexed as

antigen receptors (AgRs)cell specificityepigeneticshistone modificationstranscription

Identifiers

PMID38770228
PMCPMC11103674

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.