Evidence map›Paper›PMID 38770223›Full record

ArticleEthics in biology, engineering & medicine2019

Ethics of Using Animal Models as Predictors of Human Response in Tissue Engineering.

Jessica M Falcon, James P Karchner, Elizabeth A Henning, Robert L Mauck, Nancy Pleshko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ethics in biology, engineering & medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jessica M FalconTissue Imaging and Spectroscopy Lab, Department of Bioengineering, Temple University, Philadelphia, PA 19122.
James P KarchnerTissue Imaging and Spectroscopy Lab, Department of Bioengineering, Temple University, Philadelphia, PA 19122.
Elizabeth A HenningMcKay Orthopedic Research Laboratory, University of Pennsylvania, Philadelphia, PA 19104.
Robert L MauckMcKay Orthopedic Research Laboratory, University of Pennsylvania, Philadelphia, PA 19104.
Nancy PleshkoTissue Imaging and Spectroscopy Lab, Department of Bioengineering, Temple University, Philadelphia, PA 19122.

Funding

Evaluation of Cartilage Tissue Engineering Strategies by IR ImagingR01AR056145 · NIAMS · TEMPLE UNIV OF THE COMMONWEALTH · PI PLESHKO, NANCY · 2009 to 2020
$3.3M
NIAMS NIH HHS R01 AR056145
6 · The paper itself

Abstract

Use of outcomes from animal research for prediction of human response in tissue engineering studies has many ethical considerations. This article aims to contribute to the ethical discussion by delineating the framework of animal research and the ethical considerations at play, in particular with respect to cartilage tissue engineering. The history of animal research regulation and the current status of animal research in orthopedic tissue engineering is discussed. Questions addressed include how the proper animal models are chosen, how regulatory bodies ensure animal wellness and safety, and how guidelines are implemented and maintained throughout the life cycle of a project. Finally, we provide examples of both

Indexed as

cartilageengineeredorthopedicosteoarthritistreatment

Identifiers

PMID38770223
PMCPMC11103864

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.