Evidence map›Paper›PMID 38770217›Full record

ArticleFrontiers in molecular biosciences2024

The bioelectric mechanisms of local calcium dynamics in cancer cell proliferation: an extension of the A549

Sonja Langthaler, Christian Zumpf, Theresa Rienmüller, Niroj Shrestha, Julia Fuchs, Rui Zhou, Brigitte Pelzmann, Klaus Zorn-Pauly, Eleonore Fröhlich, Seth H Weinberg and 1 more

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Article in Frontiers in molecular biosciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cancer: A bioelectric disease?Clinical and translational medicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sonja LangthalerInstitute of Health Care Engineering with European Testing Center for Medical Devices, Graz University of Technology, Graz, Austria.
Christian ZumpfInstitute of Health Care Engineering with European Testing Center for Medical Devices, Graz University of Technology, Graz, Austria.
Theresa RienmüllerInstitute of Health Care Engineering with European Testing Center for Medical Devices, Graz University of Technology, Graz, Austria.
Niroj ShresthaInstitute of Health Care Engineering with European Testing Center for Medical Devices, Graz University of Technology, Graz, Austria.
Julia FuchsInstitute of Health Care Engineering with European Testing Center for Medical Devices, Graz University of Technology, Graz, Austria.
Rui ZhouInstitute of Health Care Engineering with European Testing Center for Medical Devices, Graz University of Technology, Graz, Austria.
Brigitte PelzmannGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
Klaus Zorn-PaulyGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
Eleonore FröhlichCenter for Medical Research, Medical University of Graz, Graz, Austria.
Seth H WeinbergDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, United States.
Christian BaumgartnerInstitute of Health Care Engineering with European Testing Center for Medical Devices, Graz University of Technology, Graz, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Advances in molecular targeting of ion channels may open up new avenues for therapeutic approaches in cancer based on the cells' bioelectric properties. In addition to Methods: The initial model was extended by a multicompartmental approach, addressing the heterogenous calcium profile and dynamics in the ER-PM junction provoked by local calcium entry of store-operated calcium channels (SOCs) and uptake by SERCA pumps. Changes of cytosolic calcium levels due to diffusion from the ER-PM junction, release from the ER by RyR channels and IP3 receptors, as well as corresponding PM channels were simulated and the dynamics evaluated based on calcium imaging data. The model parameters were fitted to available data from two published experimental studies, showing the function of CRAC channels and indirectly of IP3R, RyR and PMCA via changes of the cytosolic calcium levels. Results: The proposed calcium description accurately reproduces the dynamics of calcium imaging data and simulates the SOCE mechanisms. In addition, simulations of the combined A549-SOCE model in distinct phases of the cell cycle demonstrate how Ca Discussion: Local calcium distribution and time evolution in microdomains of the cell significantly impact the overall electrophysiological properties and exert control over cell cycle progression. By providing a more profound description, the extended A549-SOCE model represents an important step on the route towards a valid model for oncological research and

Indexed as

A549 cell linecalcium dynamicscancerelectrophysiologyin silico models

Identifiers

PMID38770217
PMCPMC11102976

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