ArticleImmunology1985
L3T4-positive T lymphoblasts are responsible for transfer of immunity to Trichinella spiralis in mice.
Article in Immunology, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 81 citations in OpenAlex.
- Immune System Investigation Using Parasitic Helminths.Annual review of immunology · 2021Review
- Article
- The influence of MHC and immunoglobulins a and e on host resistance to gastrointestinal nematodes in sheep.Journal of parasitology research · 2011Article
- CD4 T cells mediate mucosal and systemic immune responses to experimental hookworm infection.Parasite immunology · 2010Article
- Article
- Interleukin-13: a key mediator in resistance to gastrointestinal-dwelling nematode parasites.Clinical reviews in allergy & immunology · 2004Review
- Impaired protective immunity and T helper 2 responses in alymphoplasia (aly) mutant mice infected with Trichinella spiralis.Immunology · 2001Article
- Critical role for signal transducer and activator of transcription factor 6 in mediating intestinal muscle hypercontractility and worm expulsion in Trichinella spiralis-infected mice.Infection and immunity · 2001Article
- Mucosal immunity against parasitic gastrointestinal nematodes.The Korean journal of parasitology · 2000Review
- CD4 T cells and major histocompatibility complex class II expression influence worm expulsion and increased intestinal muscle contraction during Trichinella spiralis infection.Infection and immunity · 1999Article
- Th2-mediated host protective immunity to intestinal nematode infections.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1997Review
- Monoclonal antibody to CD4+ T cells abrogates genetic resistance to Haemonchus contortus in sheep.Immunology · 1993Article
- Article
- Article
- Genetic control of eosinophilia. Analysis of production and response to eosinophil-differentiating factor in strains of mice infected with Trichinella spiralis.Clinical and experimental immunology · 1989Article
- Intestinal immunity to Trichinella spiralis is a property of OX8- OX22- T-helper cells that are generated in the intestine.Immunology · 1989Article
- Mediation of immunity to Eimeria vermiformis in mice by L3T4+ T cells.Infection and immunity · 1988Article
- Immunomodulation by Trichinella spiralis: primary versus secondary response to phosphorylcholine-containing antigens.Medical microbiology and immunology · 1988Article
- Characterization of a cell population in thoracic duct lymph that adoptively transfers rejection of adult Trichinella spiralis to normal rats.Immunology · 1987Article
- Antigen-specific T-cell lines transfer protective immunity against Trichinella spiralis in vivo.Immunology · 1986Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The characteristics of lymphocyte subpopulations involved in mediating immunity to the intestinal nematode Trichinella spiralis in vivo have been examined using adoptive transfer in conjunction with accurate cell-sorting and cell-depletion techniques. Positive selection of cell subsets, using FACS sorting and velocity sedimentation at unit gravity, confirm that rapidly dividing T blasts are the major population that mediates expulsion of the worm from the gut. Furthermore, cell-depletion studies demonstrated that the T-cell subset involved is of the L3T4 + ve Lyt 2-ve phenotype. This phenotype suggests class II MHC restriction in recognition of T. spiralis antigens by T cells in vivo. The roles that such T cells play in immunity to T. spiralis are discussed in terms of lymphokine release.
Indexed as
Identifiers
3876979PMC1453703W2405073288What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.