Evidence map›Paper›PMID 38769431›Full record

Trial reportNature medicine2024

Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial.

Chet Moritz, Edelle C Field-Fote, Candace Tefertiller, Ilse van Nes, Randy Trumbower, Sukhvinder Kalsi-Ryan, Mariel Purcell, Thomas W J Janssen, Andrei Krassioukov, Leslie R Morse and 11 more

3 registry-linked trialsAbstract readMulticenter StudyClinical Trial
In one paragraph

Trial report in Nature medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 96 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07147816 naterminatednot on this mapstarted 2025, after this paper: background citation

Effects of Transcutaneous Cervical Spinal Cord Stimulation on Upper Limb Motor Function After Traumatic Brain Injury

TypeinterventionalSponsorRoberto de FreitasRan2025 to 2026Enrolled14ConditionsTraumatic Brain Injury, TBI (Traumatic Brain Injury)ArmsTranscutaneous electrical stimulation of the cervical spinal cord (tSCS)
NCT07152145 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Transcutaneous Electrical Spinal Stimulation (tSCS) for Improving Upper Limb Function in People With MS

TypeinterventionalSponsorParc de Salut MarRan2025 to 2026Enrolled60ConditionsMultiple SclerosisArmsActive stimulation tSCS, Sham: stimulations using a non-active electric stimulation, Occupational/Upper Limb Rehabilitation Therapy
NCT07208188 early_phase1not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Transcutaneous Spinal Cord Stimulation for Rehabilitation of Upper Limbs in Early Spinal Cord Injury: Randomised Feasibility Study

TypeinterventionalSponsorNHS Greater Glasgow and ClydeRan2025 to 2027Enrolled20ConditionsSpinal Cord Injuries (SCI)ArmsTranscutaneous spinal cord stimulation (tESCS) active group, Sham transcutaneous spinal cord stimulation (tESCS)
3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. AI in Medical Questionnaires: Scoping ReviewJournal of medical Internet research · 2025
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  13. Beyond Scar Removal: Reprogramming the Glial Scar for Neural Repair.International journal of molecular sciences · 2026
    Review
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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Chet Moritz *Departments of Rehabilitation Medicine, Electrical & Computer Engineering, Physiology & Biophysics and Center for Neurotechnology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3559-9442
Edelle C Field-Fote *Shepherd Center, Crawford Research Institute and Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-7219-4487
Candace Tefertiller *Department of Physical Therapy, Craig Hospital, Englewood, CO, USA.
Ilse van NesSint Maartenskliniek, Revalidatiegeneeskunde, Nijmegen, The Netherlands.ORCID 0000-0003-3249-3789
Randy TrumbowerDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA.
Sukhvinder Kalsi-RyanKITE Research Institute|Toronto Rehab, University Health Network, Toronto, Ontario, Canada.
Mariel PurcellScottish Centre for Innovation in Spinal Cord Injury, Queen Elizabeth National Spinal Injuries Unit, Queen Elizabeth University Hospital, Glasgow, UK.
Thomas W J JanssenAmsterdam Rehabilitation Research Center | Reade, Amsterdam, The Netherlands.ORCID 0000-0001-6762-131X
Andrei KrassioukovICORD and Division of Physical Medicine and Rehabilitation, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-0022-7972
Leslie R MorseDepartment of Rehabilitation Medicine, University of Minnesota School of Medicine, Minneapolis, MN, USA.
Kristin D ZhaoDepartment of Physical Medicine and Rehabilitation, Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, MN, USA.
James GuestDepartment of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.ORCID 0000-0003-0931-0286
Ralph J MarinoThomas Jefferson University Hospital, Philadelphia, PA, USA.
Lynda M MurrayDepartments of Rehabilitation and Human Performance and Medicine, James J. Peters VA Medical Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jill M WechtDepartment of Research and Development, James J. Peters VA Medical Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Markus RiegerONWARD Medical, Lausanne, Switzerland.
Jared PradarelliONWARD Medical, Lausanne, Switzerland.ORCID 0000-0002-0747-1644
Amanda TurnerONWARD Medical, Lausanne, Switzerland.
Jessica D'AmicoONWARD Medical, Lausanne, Switzerland.
Jordan W SquairNeuroX Institute and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Geneva, Switzerland.ORCID 0000-0003-0551-859X
Gregoire CourtineNeuroX Institute and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Geneva, Switzerland. gregoire.courtine@epfl.ch.ORCID 0000-0002-5744-4142

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical spinal cord injury (SCI) leads to permanent impairment of arm and hand functions. Here we conducted a prospective, single-arm, multicenter, open-label, non-significant risk trial that evaluated the safety and efficacy of ARC

Indexed as

ArmHandQuadriplegiaSpinal Cord InjuriesAdultAgedChronic DiseaseElectric Stimulation TherapyFemaleHumansMaleMiddle AgedProspective StudiesQuality of LifeSpinal Cord StimulationTreatment Outcome

Identifiers

PMID38769431
PMCPMC11108781

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.