Evidence map›Paper›PMID 38769400›Full record

Trial reportPediatric research2024

Robot-assisted gait training improves walking and cerebral connectivity in children with unilateral cerebral palsy.

Laura Julien, Guillemette Moreau-Pernet, Emmanuelle Rochette, Jean-Jacques Lemaire, Bénédicte Pontier, Sacha Bourrand, Bruno Pereira, Carine Chassain, Anna Sontheimer, Catherine Sarret

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04246788 (Intensive Robotic Rehabilitation in Children With Hemiparesia Using GEOSYSTEM), which is not on this map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04246788 nacompletednot on this map

Intensive Robotic Rehabilitation in Children With Hemiparesia Using GEOSYSTEM

TypeinterventionalSponsorUniversity Hospital, Clermont-FerrandRan2020 to 2021Enrolled40ConditionsInfantile HemiplegiaArmsIntensive robotic rehabilitation, classical physiotherapy
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laura JulienDepartment of Pediatrics, CRECHE, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.
Guillemette Moreau-PernetPhysiotherapy Center, Association Ekipe Medical Recherche, Clermont-Ferrand, France.
Emmanuelle RochetteDepartment of Pediatrics, CRECHE, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.
Jean-Jacques LemaireClermont Auvergne University, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, France.
Bénédicte PontierDepartment of Pediatrics, CRECHE, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.
Sacha BourrandClermont Auvergne University, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, France.
Bruno PereiraClinical Research Division, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.
Carine ChassainClermont Auvergne University, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, France.
Anna SontheimerClermont Auvergne University, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, France.
Catherine SarretDepartment of Pediatrics, CRECHE, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France. csarret@chu-clermontferrand.fr.ORCID 0000-0002-1919-4189

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRobot-assisted gait training (RAGT) is promising to help walking rehabilitation in cerebral palsy, but training-induced neuroplastic effects have little been investigated.

methodsForty unilateral cerebral palsy children aged 4-18 years were randomly allocated in a monocentric study to ten 20-minute RAGT sessions with the G-EO system, five days a week (n = 20) or to a control group (who continued conventional care with six 30-minute physiotherapy sessions, three days a week) (n = 20), two weeks running, from September 2020 to December 2021. Clinical and MRI outcomes were compared before and one month after therapy. The primary outcome was gait speed. Secondary outcomes were a 6-minute walking test distance, Gross Motor Function Measure-88 (GMFM-88) dimensions D and E, Patient Global Impression of Improvement, resting-state functional connectivity within the sensorimotor network, and structural connectivity in the corticospinal tracts.

resultsGait speed and the 6-minute walking test distance improved more after RAGT. Resting-state functional connectivity increased after RAGT but decreased in controls between superior and lateral healthy or lateral injured sensorimotor networks. GMFM-88 and structural connectivity in corticospinal tracts were unchanged. Impression of improvement in children was better after RAGT.

conclusionShort-term benefit of repetitive RAGT on walking abilities and functional cerebral connectivity was found in unilateral cerebral palsy children. IMPACT STATEMENT: Short-term repetitive robot-assisted gait training improves gait speed and walking resistance and increases cerebral functional connectivity in unilateral cerebral palsy. GMFM dimensions D and E were unchanged after short-term repetitive robot-assisted gait training in unilateral cerebral palsy.

Indexed as

Cerebral PalsyGaitRoboticsWalkingAdolescentChildChild, PreschoolExercise TherapyFemaleHumansMagnetic Resonance ImagingMaleNeuronal PlasticityTreatment Outcome

Identifiers

PMID38769400

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.