Evidence map›Paper›PMID 38769385›Full record

ArticleCommunications biology2024

Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo.

Rutulkumar Patel, Daniel E Cooper, Kushal T Kadakia, Annamarie Allen, Likun Duan, Lixia Luo, Nerissa T Williams, Xiaojing Liu, Jason W Locasale, David G Kirsch

Abstract read
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Glutamine metabolism in health and disease.Signal transduction and targeted therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rutulkumar Patel *Department of Radiation Oncology, Baylor College of Medicine, 7200 Cambridge St, Houston, TX, 77030, USA.ORCID 0000-0001-6652-6070
Daniel E Cooper *Department of Radiation Oncology, Duke University, Box 3085, Duke Cancer Center, Medicine Circle, Durham, NC, 27710, USA.
Kushal T KadakiaDepartment of Radiation Oncology, Duke University, Box 3085, Duke Cancer Center, Medicine Circle, Durham, NC, 27710, USA.
Annamarie AllenDepartment of Pharmacology and Cancer Biology, Duke University, Box 3813, 308 Research Drive, Durham, NC, 27710, USA.
Likun DuanDepartment of Pharmacology and Cancer Biology, Duke University, Box 3813, 308 Research Drive, Durham, NC, 27710, USA.
Lixia LuoDepartment of Radiation Oncology, Duke University, Box 3085, Duke Cancer Center, Medicine Circle, Durham, NC, 27710, USA.
Nerissa T WilliamsDepartment of Radiation Oncology, Duke University, Box 3085, Duke Cancer Center, Medicine Circle, Durham, NC, 27710, USA.
Xiaojing LiuDepartment of Molecular and Structural Biochemistry, NC State University, Box 7622, 128 Polk Hall, Raleigh, NC, 27695, USA.ORCID 0000-0002-4231-6017
Jason W LocasaleDepartment of Pharmacology and Cancer Biology, Duke University, Box 3813, 308 Research Drive, Durham, NC, 27710, USA.
David G KirschDepartment of Radiation Oncology, Duke University, Box 3085, Duke Cancer Center, Medicine Circle, Durham, NC, 27710, USA. David.Kirsch@uhn.ca.ORCID 0000-0002-2086-205X

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI JOHN N. NORTON · 1985 to 2026
$174.8M
Advancing Cancer Therapy through Ground Breaking Research in Radiation BiologyR35CA197616 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI David Guy Kirsch · 2016 to 2026
$10.7M
Dietary methionine and cancerR01CA193256 · NCI · DUKE UNIVERSITY · PI LOCASALE, JASON W. · 2015 to 2023
$3.1M
Training Grant In Radiation BiologyT32CA093240 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FREEMAN, MICHAEL L. · 2002 to 2016
$2.3M
Image-Guided Radiation Therapy System for Small AnimalsS10OD028575 · OD · DUKE UNIVERSITY · PI PALMER, GREGORY MATHEW · 2021 to 2021
$600k
American Association for Cancer Research (American Association for Cancer Research, Inc.) 21-40-37-PATEAmerican Cancer Society (American Cancer Society, Inc.) RSG-16-214-01-TBEFoundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) CA193256Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R35CA197616Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) T32CA093240NCI NIH HHS P30 CA014236NCI NIH HHS R01 CA193256NCI NIH HHS R35 CA197616NCI NIH HHS T32 CA093240NIH HHS S10 OD028575
6 · The paper itself

Abstract

Diverse tumor metabolic phenotypes are influenced by the environment and genetic lesions. Whether these phenotypes extend to rhabdomyosarcoma (RMS) and how they might be leveraged to design new therapeutic approaches remains an open question. Thus, we utilized a Pax7

Indexed as

GlutaminaseGlutamineSarcomaAnimalsDisease Models, AnimalGlucoseMiceRadiation ToleranceGLS1 protein, mouseGlucoseGlutaminaseGlutamine

Identifiers

PMID38769385
PMCPMC11106276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.