Evidence map›Paper›PMID 38769370›Full record

ArticleScientific reports2024

Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source.

Juan Peñas, Aarón Alejo, Adrián Bembibre, Jon Imanol Apiñaniz, Enrique García-García, Carlos Guerrero, José Luis Henares, Irene Hernández-Palmero, Cruz Méndez, María Ángeles Millán-Callado and 3 more

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Juan PeñasInstituto Galego de Física de Altas Enerxías (IGFAE), Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Aarón AlejoInstituto Galego de Física de Altas Enerxías (IGFAE), Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Adrián BembibreInstituto Galego de Física de Altas Enerxías (IGFAE), Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Jon Imanol ApiñanizCentro de Láseres Pulsados (CLPU), 37185, Salamanca, Spain.
Enrique García-GarcíaCentro de Láseres Pulsados (CLPU), 37185, Salamanca, Spain.
Carlos GuerreroDpto. Física Atómica, Molecular y Nuclear (FAMN), Universidad de Sevilla, 41012, Sevilla, Spain.
José Luis HenaresCentro de Láseres Pulsados (CLPU), 37185, Salamanca, Spain.
Irene Hernández-PalmeroCentro de Láseres Pulsados (CLPU), 37185, Salamanca, Spain.
Cruz MéndezCentro de Láseres Pulsados (CLPU), 37185, Salamanca, Spain.
María Ángeles Millán-CalladoDpto. Física Atómica, Molecular y Nuclear (FAMN), Universidad de Sevilla, 41012, Sevilla, Spain.
Pilar Puyuelo-ValdésCentro de Láseres Pulsados (CLPU), 37185, Salamanca, Spain.
Michael SeimetzInstituto de Instrumentación para Imagen Molecular (I3M), CSIC - Universitat Politècnica de València, 46022, Valencia, Spain.
José BenlliureInstituto Galego de Física de Altas Enerxías (IGFAE), Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain. j.benlliure@usc.es.

Funding

Generalitat Valenciana AICO/2020/207'la Caixa' Foundation ID 100010434Ministerio de Ciencia e Innovación RTI2018-098117-B-C21Ministerio de Ciencia e Innovación RTI2018-101578-B-C21Ministerio de Ciencia e Innovación RTI2018-101578-B-C22Ministerio de Ciencia e Innovación RYC2021-032654-IMinisterio de Ciencia, Innovación y Universidades MDM- 2016-0692-17-2Xunta de Galicia GRC ED431C 2017/54
6 · The paper itself

Abstract

Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based on laser-driven ion acceleration for the production of radioisotopes for PET imaging. We report for the first time the use of a high-repetition rate, ultra-intense laser system for the production of carbon-11 in multi-shot operation. Proton bunches with energies up to 10-14 MeV were systematically accelerated in long series at pulse rates between 0.1 and 1 Hz using a PW-class laser. These protons were used to activate a boron target via the

Identifiers

PMID38769370
PMCPMC11631950

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.