Evidence map›Paper›PMID 38769314›Full record

ArticleBDJ open2024

Hyperpure chlorine dioxide versus chlorhexidine in intra-oral halitosis (ODOR trial) - protocol of a double-blinded, double-arm, parallel non-inferiority pilot randomized controlled trial.

Eszter Ágnes Szalai, Brigitta Teutsch, Viktória Babay, Adél Galvács, Péter Hegyi, Péter Hársfalvi, Róbert Pál, Gábor Varga, Zsolt M Lohinai, Beáta Kerémi

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BDJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06219226 (Hyperpure Chlorine Dioxide Versus Chlorhexidine in Intra-oral Halitosis), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06219226 naenrolling by invitationnot on this map

Hyperpure Chlorine Dioxide Versus Chlorhexidine in Intra-oral Halitosis (ODOR Trial)

TypeinterventionalSponsorSemmelweis UniversityRan2024 to 2025Enrolled60ConditionsHalitosisArmsChlorine dioxide mouthwash, Chlorhexidine mouthwash
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eszter Ágnes SzalaiDepartment of Restorative Dentistry and Endodontics, Semmelweis University, Budapest, Hungary.ORCID http://orcid.org/0000-0003-2276-7109
Brigitta TeutschCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.
Viktória BabayFaculty of Dentistry, Semmelweis University, Budapest, Hungary.
Adél GalvácsFaculty of Dentistry, Semmelweis University, Budapest, Hungary.
Péter HegyiCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.
Péter HársfalviUniversity of Veterinary Medicine Budapest, Department of Biostatistics, Budapest, Hungary.
Róbert PálToday Science Ltd., Diósd, Hungary.
Gábor VargaCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.ORCID http://orcid.org/0000-0002-5506-8198
Zsolt M LohinaiDepartment of Restorative Dentistry and Endodontics, Semmelweis University, Budapest, Hungary.
Beáta KerémiDepartment of Restorative Dentistry and Endodontics, Semmelweis University, Budapest, Hungary. keremi.beata@semmelweis.hu.ORCID http://orcid.org/0000-0003-4000-9440

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIntra-oral halitosis (IOH) is the most common type of bad breath; its consequences impair quality of life. However, evidence-based treatment protocols and guidelines are lacking. Our aim is to investigate the effectiveness of chlorine dioxide as an applicable complementary treatment modality in IOH after tongue cleaning. METHODS AND ANALYSIS: The ODOR trial will be a single-center, double-blinded, parallel-group, double-armed pilot randomized controlled trial with a non-inferiority design. The efficacy of hyperpure chlorine dioxide will be compared to chlorhexidine mouthwash. We plan to investigate the short-term effects of the intervention over a 3-h period. The primary endpoint will be changes in organoleptic test scores. At the end of the pilot investigation of the first 30 patients each, sample size calculation will be performed. If feasible, the investigators will continue the study by enrolling more patients.

trial registrationThe trial has been registered at ClinicalTrials.gov (NCT06219226).

Identifiers

PMID38769314
PMCPMC11106080

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.