Evidence map›Paper›PMID 38769288›Full record

ArticleNature communications2024

Elevated Na is a dynamic and reversible modulator of mitochondrial metabolism in the heart.

Yu Jin Chung, Zoe Hoare, Friedrich Baark, Chak Shun Yu, Jia Guo, William Fuller, Richard Southworth, Doerthe M Katschinski, Michael P Murphy, Thomas R Eykyn and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Glycolytic activation of β-cell NaMolecular metabolism · 2026
    Article
  6. Line-narrowing by polychromatic selective spin-locking in NMR.Magnetic resonance (Gottingen, Germany) · 2026
    Article
  7. Article
  8. Article
  9. Mechano-energetic uncoupling in heart failure.Nature reviews. Cardiology · 2025
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Role of NaInternational journal of molecular sciences · 2024
    Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yu Jin ChungSchool of Cardiovascular and Metabolic Medicine and Sciences, King's College, London, UK.
Zoe HoareSchool of Cardiovascular and Metabolic Medicine and Sciences, King's College, London, UK.ORCID http://orcid.org/0009-0002-8645-5817
Friedrich BaarkSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Chak Shun YuMRC Mitochondrial Biology Unit and Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0009-0004-3106-9681
Jia GuoInstitute of Cardiovascular Physiology, University Medical Centre, Göttingen, Germany.ORCID http://orcid.org/0000-0002-4055-9103
William FullerSchool of Cardiovascular and Metabolic Health, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0002-5883-4433
Richard SouthworthSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0002-7904-8335
Doerthe M KatschinskiInstitute of Cardiovascular Physiology, University Medical Centre, Göttingen, Germany.ORCID http://orcid.org/0000-0003-4630-9081
Michael P MurphyMRC Mitochondrial Biology Unit and Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-1115-9618
Thomas R EykynSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. thomas.eykyn@kcl.ac.uk.ORCID http://orcid.org/0000-0003-1768-3808
Michael J ShattockSchool of Cardiovascular and Metabolic Medicine and Sciences, King's College, London, UK. michael.shattock@kcl.ac.uk.ORCID http://orcid.org/0000-0001-6242-7585

Funding

British Heart Foundation (BHF) RE/18/2/34213British Heart Foundation (BHF) RG/12/4/29426British Heart Foundation (BHF) RG/17/15/33106Deutsche Forschungsgemeinschaft (German Research Foundation) GRK2824Deutsche Forschungsgemeinschaft (German Research Foundation) KA1269/13-1RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/S019901/1RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/S032789/1RCUK | Medical Research Council (MRC) MC_UU_00028/4RCUK | MRC | Medical Research Foundation MC_UU_00028/4Wellcome TrustWellcome Trust (Wellcome) 203148/Z/16/ZWellcome Trust (Wellcome) 220257/Z/20/Z
6 · The paper itself

Abstract

Elevated intracellular sodium Na

Indexed as

Mitochondria, HeartSodiumAdenosine TriphosphateAnimalsCitric Acid CycleHeart FailureHypoxia-Inducible Factor 1, alpha SubunitMaleMyocardiumOrganophosphorus CompoundsOxidation-ReductionRatsRats, Sprague-DawleySodium-Calcium ExchangerSodium-Potassium-Exchanging ATPaseSuccinic AcidAdenosine TriphosphateHif1a protein, ratHypoxia-Inducible Factor 1, alpha SubunitmitoquinoneOrganophosphorus CompoundsSodiumSodium-Calcium ExchangerSodium-Potassium-Exchanging ATPaseSuccinic AcidUbiquinone

Identifiers

PMID38769288
PMCPMC11106256

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.