SynthesisTechniques in coloproctology2024
The economic impact of anastomotic leakage after colorectal surgery: a systematic review.
Synthesis in Techniques in coloproctology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07486570 (Anastomotic Leakage Prevention by Endovascular Stenting of the Superior Mesenteric Artery), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Anastomotic Leakage Prevention by Endovascular Stenting of the Superior Mesenteric Artery
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Novel adjunctive technologies for the prevention of colorectal anastomotic leakage: a systematic review.Techniques in coloproctology · 2026Pooled it
- Management of anastomotic leak after elective anterior resection for rectal cancer: A systematic review and pooled analysis.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Pooled it
- Costs and health burden of surgical site infections and anastomotic leakage in major abdominal surgery.BJS open · 2026Trial
- Anastomotic reinforcement in rectal surgery: a position statement from an expert panel of colorectal surgeons.Updates in surgery · 2026Article
- Treatment of colorectal leaks with the VACStent-Colon: results of the VACStent feasibility trial.Surgical endoscopy · 2026Article
- Management of anastomotic leak following restorative rectal cancer resection-a multi-centre retrospective audit in Ireland.Irish journal of medical science · 2026Article
- Cumulative Surgeon Experience and Anastomotic Leakage After Left-Sided and Segmental Colorectal Resection with Primary Anastomosis: A Seven-Year Single-Center Retrospective Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Costs associated with anastomotic leak after left-sided colorectal surgery: retrospective real-world study in England.BJS open · 2026Article
- Preoperative CT Evaluation of Abdominal Vasculature and the Risk of Surgical Complications in Colorectal Cancer Resection with Anastomosis: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2026Review
- Perioperative microbiota at the colorectal anastomosis: local host-microbe interactions in healing and leak.Frontiers in surgery · 2026Review
- Fluorescence-guided ureter mapping in colorectal surgery: a systematic review of intraureteral ICG and emerging renal fluorophores.Frontiers in surgery · 2026Review
- Hospital costs of different treatment strategies for anastomotic leakage after total mesorectal excision: a multicentre cost analysis.Techniques in coloproctology · 2025Article
- Ethical Pitfalls in AI-Based Predictive Models in Surgery.World journal of surgery · 2025Review
- A Novel Deep Learning Model for Predicting Colorectal Anastomotic Leakage: A Pioneer Multicenter Transatlantic Study.Journal of clinical medicine · 2025Article
- Improved outcomes with cyanoacrylate glue for ileocolic anastomosis in right colectomy: a multicenter study.Annals of coloproctology · 2025Article
- Elevated drain fluid calprotectin as a predictor of early anastomotic leakage in colorectal surgery.World journal of surgical oncology · 2025Article
- Patient perspectives on AI-based decision support in surgery.BMJ surgery, interventions, & health technologies · 2025Article
- Review
- Negative and Positive Predictors of Anastomotic Leakage in Colorectal Cancer Patients-The Case of Neutrophil-to-Lymphocyte Ratio.Diagnostics (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnastomotic leakage (AL) remains a burdensome complication following colorectal surgery, with increased morbidity, oncological compromise, and mortality. AL may impose a substantial financial burden on hospitals and society due to extensive resource utilization. Estimated costs associated with AL are important when exploring preventive measures and treatment strategies. The purpose of this study was to systematically review the existing literature on (socio)economic costs associated with AL after colorectal surgery, appraise their quality, compare reported outcomes, and identify knowledge gaps.
methodsHealth economic evaluations reporting costs related to AL after colorectal surgery were identified through searching multiple online databases until June 2023. Pairs of reviewers independently evaluated the quality using an adapted version of the Consensus on Health Economic Criteria list. Extracted costs were converted to 2022 euros (€) and also adjusted for purchasing power disparities among countries.
resultsFrom 1980 unique abstracts, 59 full-text publications were assessed for eligibility, and 17 studies were included in the review. The incremental costs of AL after correcting for purchasing power disparity ranged from €2250 (+39.9%, Romania) to €83,633 (+ 513.1%, Brazil). Incremental costs were mainly driven by hospital (re)admission, intensive care stay, and reinterventions. Only one study estimated the economic societal burden of AL between €1.9 and €6.1 million.
conclusionsAL imposes a significant financial burden on hospitals and social care systems. The magnitude of costs varies greatly across countries and data on the societal burden and non-medical costs are scarce. Adherence to international reporting standards is essential to understand international disparities and to externally validate reported cost estimates.
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