Evidence map›Paper›PMID 38768941›Full record

ReviewJournal of gynecologic oncology2024

Targeting BRAF pathway in low-grade serous ovarian cancer.

Chiara Perrone, Roberto Angioli, Daniela Luvero, Andrea Giannini, Violante Di Donato, Ilaria Cuccu, Ludovico Muzii, Francesco Raspagliesi, Giorgio Bogani

Abstract readReview
In one paragraph

Review in Journal of gynecologic oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  13. Advances in laboratory medicine · 2025
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  14. Advances in laboratory medicine · 2025
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  15. The -124C>T Mutation of theCurrent oncology (Toronto, Ont.) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chiara PerroneDepartment of Gynecological, Obstetrical and Urological Sciences, Sapienza University of Rome, Rome, Italy.ORCID 0000-0001-7055-4023
Roberto AngioliDepartment of Gynecology, Campus Bio-Medico University Hospital Foundation, Rome, Italy.ORCID 0000-0002-8528-4318
Daniela LuveroDepartment of Gynecology, Campus Bio-Medico University Hospital Foundation, Rome, Italy.ORCID 0000-0002-3537-7014
Andrea GianniniDepartment of Gynecological, Obstetrical and Urological Sciences, Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-4388-0082
Violante Di DonatoDepartment of Gynecological, Obstetrical and Urological Sciences, Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-9254-5790
Ilaria CuccuDepartment of Gynecological, Obstetrical and Urological Sciences, Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-3711-5309
Ludovico MuziiDepartment of Gynecological, Obstetrical and Urological Sciences, Sapienza University of Rome, Rome, Italy.ORCID 0000-0001-7195-9583
Francesco RaspagliesiGynecologic Oncologic Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.ORCID 0000-0001-8953-1657
Giorgio BoganiGynecologic Oncologic Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy. giorgiobogani@yahoo.it.ORCID 0000-0001-8373-8569

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in genes encoding for proteins along the RAS-RAF-MEK-ERK pathway have been detected in a variety of tumor entities including ovarian carcinomas. In the recent years, several inhibitors of this pathway have been developed, whose antitumor potential is currently being assessed in different clinical trials. Low grade serous ovarian carcinoma, is a rare gynecological tumor which shows favorable overall survival, compared to the general ovarian cancer population, but worrying resistance to conventional chemotherapies. The clinical behavior of low grade serous ovarian carcinoma reflects the different gene profile compared to high-grade serous carcinoma:

Indexed as

Cystadenocarcinoma, SerousOvarian NeoplasmsProto-Oncogene Proteins B-rafAntineoplastic Combined Chemotherapy ProtocolsFemaleHumansImidazolesMAP Kinase Signaling SystemMitogen-Activated Protein Kinase KinasesMolecular Targeted TherapyNeoplasm GradingOximesProtein Kinase InhibitorsSulfonamidesBRAF protein, humandabrafenibImidazolesMitogen-Activated Protein Kinase KinasesOximesProtein Kinase InhibitorsProto-Oncogene Proteins B-rafSulfonamidesBRAF Protein, HumanMEK InhibitorOvarian Neoplasms

Identifiers

PMID38768941
PMCPMC11262891

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.