Evidence map›Paper›PMID 38768274›Full record

ArticleCirculation2024

Detection of Circulating Transthyretin Amyloid Aggregates in Plasma: A Novel Biomarker for Transthyretin Amyloidosis.

Rose Pedretti, Lanie Wang, Mazen Hanna, Merrill D Benson, Justin L Grodin, W H Wilson Tang, Ahmad Masri, Lorena Saelices

Registry-linked trialAbstract readLetter
In one paragraph

Article in Circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07196839 (Determining the Association of TTR Stabilizing Therapy With Circulating TTR Amyloid Aggregates Over Time in Patients With ATTR-CM), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07196839 recruitingnot on this mapstarted 2025, after this paper: background citation

Determining the Association of TTR Stabilizing Therapy With Circulating TTR Amyloid Aggregates Over Time in Patients With ATTR-CM: Longitudinal Biomarker Study

TypeobservationalSponsorUniversity of Texas Southwestern Medical CenterRan2025 to 2027Enrolled50ConditionsTransthyretin (TTR) Amyloid Cardiomyopathy
3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Transthyretin amyloid fibrils adopt distinct folds in the brain.bioRxiv : the preprint server for biology · 2026
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  14. Detection of ATTR aggregates in the plasma of polyneuropathic patients with ATTR-V30M amyloidosis.Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis · 2024
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rose PedrettiCenter for Alzheimer's and Neurodegenerative Diseases, Department of Biophysics, Peter O'Donnell Jr. Brain Institute (R.P., L.W., L.S.), University of Texas Southwestern Medical Center, Dallas.ORCID 0000-0001-6354-3588
Lanie WangCenter for Alzheimer's and Neurodegenerative Diseases, Department of Biophysics, Peter O'Donnell Jr. Brain Institute (R.P., L.W., L.S.), University of Texas Southwestern Medical Center, Dallas.ORCID 0000-0003-2532-7889
Mazen HannaDepartment of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic, OH (M.H., W.H.W.T.).
Merrill D BensonDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis (M.D.B.).
Justin L GrodinDivision of Cardiology, Department of Internal Medicine (J.L.G.), University of Texas Southwestern Medical Center, Dallas.ORCID 0000-0003-2400-3196
W H Wilson TangDepartment of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic, OH (M.H., W.H.W.T.).ORCID 0000-0002-8335-735X
Ahmad MasriDivision of Cardiovascular Medicine, Oregon Health and Sciences University, Portland (A.M.).ORCID 0000-0002-6390-6526
Lorena SaelicesCenter for Alzheimer's and Neurodegenerative Diseases, Department of Biophysics, Peter O'Donnell Jr. Brain Institute (R.P., L.W., L.S.), University of Texas Southwestern Medical Center, Dallas.ORCID 0000-0002-1904-2150

Funding

IDENTIFYING SUBCLINICAL TRANSTHYRETIN CARDIAC AMYLOIDOSIS IN ASYMPTOMATIC CARRIERS OF THE V122I TTR ALLELER01HL160892 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Justin Lee Grodin · 2022 to 2026
$3.6M
Closing the gap between structural biology and translational science for amyloid diseasesDP2HL163810 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SAELICES GOMEZ, LORENA · 2021 to 2024
$2.5M
NHLBI NIH HHS DP2 HL163810NHLBI NIH HHS R01 HL160892
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amyloid Neuropathies, FamilialBiomarkersPrealbuminAgedAmyloidFemaleHumansMaleMiddle AgedAmyloidBiomarkersPrealbuminTTR protein, humanamyloidamyloidosisbiomarkerstransthyretin

Identifiers

PMID38768274
PMCPMC11107565

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.