Evidence map›Paper›PMID 38767797›Full record

ArticleJournal of cardiovascular translational research2024

Differential Effects of Pharmacologic and Mechanical Support on Right-Left Ventricular Coupling.

Kimberly K Lamberti, Efrat M Goffer, Elazer R Edelman, Steven P Keller

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kimberly K LambertiInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Efrat M GofferInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Elazer R EdelmanInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Steven P KellerDepartment of Medicine (Pulmonary and Critical Care Medicine), Johns Hopkins University, 1830 E. Monument Street 1830 Building; 5th Floor, Baltimore, MD, 21215, USA. steven.keller@jhmi.edu.ORCID http://orcid.org/0000-0002-3870-9811

Funding

Personalized lesion modification optimizes atherosclerosis interventionR01HL161069 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI EDELMAN, ELAZER R · 2022 to 2025
$2.8M
Functional restoration of ventriculo-arterial coupling in cardiogenic shock via dual mechanical supportK08HL143342 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KELLER, STEVEN PAUL · 2018 to 2023
$853k
Optimization of Right and Left Ventricular Coupling During Mechanical Circulatory SupportF31HL170537 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LAMBERTI, KIMBERLY K · 2023 to 2025
$61k
NHLBI NIH HHS 5R01HL161069NHLBI NIH HHS F31 HL170537NHLBI NIH HHS F31HL170537NHLBI NIH HHS K08HL14332NHLBI NIH HHS K08 HL143342NHLBI NIH HHS R01 HL161069
6 · The paper itself

Abstract

backgroundPercutaneous ventricular assist devices are increasingly relied on to maintain perfusion for cardiogenic shock patients. Optimal medical management strategies however remain uncertain from limited understanding of interventricular effects. This study analyzed the effects of pharmacologic and left-sided mechanical support on right ventricular function.

methodsA porcine model was developed to assess biventricular function during bolus pharmacologic administration before and after left-sided percutaneous ventricular assist and in cardiogenic shock.

resultsThe presence of mechanical support increased right ventricular load and stress with respect to the left ventricle. This shifted and exaggerated the relative effects of commonly used vasoactive agents. Furthermore, induction of cardiogenic shock led to differential pulmonary vascular and right ventricular responses.

conclusionsLeft ventricular ischemia and mechanical support altered interventricular coupling. Resulting impacts of pharmacologic agents indicate differential right heart responses and sensitivity to treatments and the need for further study to optimize biventricular function in shock patients.

Indexed as

Disease Models, AnimalHeart-Assist DevicesShock, CardiogenicVentricular Function, LeftVentricular Function, RightAnimalsProsthesis DesignSus scrofaSwineTime FactorsCardiogenic shockMechanical circulatory supportVentricular-ventricular coupling

Identifiers

PMID38767797
PMCPMC11518637

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.