Evidence map›Paper›PMID 38767635›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2024

Differential metabolite analysis of the pharmacodynamic differences between different ratios of Dahuang ()-Taoren () herb pair.

Wang Xiang, Huang Jianping, Wang Yupeng, Wang Qilong, Jing Yajiang, Zhang Gang, Peng Liang, Gao Jing, Wang Hongyan, Yan Yonggang

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Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Wang XiangDepartment of Key Laboratory of "Qin Pharmaceutical" Research and Development, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China.
Huang JianpingDepartment of Key Laboratory of "Qin Pharmaceutical" Research and Development, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China.
Wang YupengDepartment of Yupeng Shaanxi Haitian Pharmaceutical Co., Ltd., Xianyang 712000, China.
Wang QilongDepartment of Key Laboratory of "Qin Pharmaceutical" Research and Development, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China.
Jing YajiangDepartment of Key Laboratory of "Qin Pharmaceutical" Research and Development, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China.
Zhang GangDepartment of Key Laboratory of "Qin Pharmaceutical" Research and Development, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China.
Peng LiangDepartment of Key Laboratory of "Qin Pharmaceutical" Research and Development, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China.
Gao JingDepartment of Key Laboratory of "Qin Pharmaceutical" Research and Development, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China.
Wang HongyanDepartment of Acupuncture and Tuina, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China.
Yan YonggangDepartment of Key Laboratory of "Qin Pharmaceutical" Research and Development, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China.

Funding

Discipline Innovation Team Project on Quality Evaluation and Resource Development of "Qin Medicine", Shaanxi University of Chinese Medicine 2019-QN01National Major Natural Science Foundation Project: Study on the Dose-effect Relationship and Compatibility Mechanism of Core Medicine in Taohe Chengqi Decoction Prescription on "Removing Stasis And Dissipating Heat" of Taoren Rhubarb 81973592Project of the Administration of Traditional Chinese Medicine of Shaanxi Province: Study on the Compatibility of the Classic Prescription Taohe Chengqi Decoction "Expelling Stasis And Expelling Heat" Based on Drug Interaction 2021-GJ-JC004
6 · The paper itself

Abstract

objectiveTo explore the material basis of the difference of efficacy of Dahuang (

methodsSamples of different ratios of Dahuang (

resultsA total of 240 primary metabolites were detected. Forty-one differential metabolites involved nine differential metabolic pathways, of which four were closely related to the efficacy of DT in the treatment of heat and blood stasis syndrome. These pathways included the biosynthesis of amino acid (phenylalanine tyrosine and tryptophan), flavonoids, unsaturated fatty acids, and the glycolysis/glycogenesis pathway.

conclusionThere are significant differences in the efficacy of different ratios of DT drugs, and their optimal ratio for the treatment of heat and blood stasis syndrome should be 1:1.

Indexed as

Drugs, Chinese HerbalMetabolomicsAnimalsGas Chromatography-Mass SpectrometryHumansMaleDrugs, Chinese HerbalDahuang ()differential metaboliteskernel drug pairsmetabolic networks and pathwaysmetabolomicsTaoren ()

Identifiers

PMID38767635
PMCPMC11077142

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