Evidence map›Paper›PMID 38767627›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2024

Transient receptor potential vanilloid 1 involved in the analgesic effects of total flavonoids extracted from Longxuejie ().

M O Xiaoqiang, Chen Yating, Yin Qian, Chen Haibo, Ban Qiang, L I Jun, Chen Su, Yao Jinguang

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Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

8 authors.

M O XiaoqiangDepartment of Stomatology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China.
Chen YatingCollege of Biomedical Engineering, South-Central Minzu University, Key Laboratory of Cognitive Science of State Ethnic Affairs Commission, Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis and Treatment, Wuhan 430074, China.
Yin QianCollege of Biomedical Engineering, South-Central Minzu University, Key Laboratory of Cognitive Science of State Ethnic Affairs Commission, Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis and Treatment, Wuhan 430074, China.
Chen HaiboDepartment of Stomatology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China.
Ban QiangDepartment of Stomatology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China.
L I JunCollege of Pharmacy, South-Central Minzu University, Wuhan 430074, China.
Chen SuCollege of Biomedical Engineering, South-Central Minzu University, Key Laboratory of Cognitive Science of State Ethnic Affairs Commission, Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis and Treatment, Wuhan 430074, China.
Yao JinguangDepartment of Stomatology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China.

Funding

High Level Talents Project of Affiliated Hospital of Youjiang Medical University for Nationalities: Study of Soft-Du'an Capsule's Mechanism and Efficacy of Regulating TRPV1 Pashways in Relieving Oral and Maxillofacial Trigeminal Neuralgia YYFYR20213002Innovative Group Project of Natural Science Foundation of Hubei Province: Study on the Mechanisms of Pain Signal Transduction and Drug Analgesia 2020CFA025
6 · The paper itself

Abstract

objectiveTo evaluate the analgesic effects of total flavonoids of Longxuejie (

methodsWhole-cell patch clamp technique was used to observe the effects of TFDB on capsaicin-induced TRPV1 currents. Rat experiments

resultsResults showed that TFDB inhibited capsaicin-induced TRPV1 receptor currents in acutely isolated dorsal root ganglion (DRG) neurons of rats and the half inhibitory concentration was (16.7 ± 1.6) mg/L. TFDB (2-20 mg/kg) showed analgesic activity in the phase Ⅱ of formalin test and (0.02-2 mg per paw) reduced capsaicin-induced licking times of rats. TFDB (20 mg/kg) was fully efficacious on complete Freund's adjuvant (CFA)-induced inflammatory thermal hyperalgesia and capsaicin could weaken the analgesic effects. The level of TRPV1 expressions of DRG neurons was also decreased in TFDB-treated CFA-inflammatory pain rats.

conclusionAll these results indicated that the analgesic effect of TFDB may contribute to their modulations on both function and expression of TRPV1 channels in DRG neurons.

Indexed as

AnalgesicsFlavonoidsGanglia, SpinalTRPV Cation ChannelsAnimalsDrugs, Chinese HerbalNeuronsPainRatsRats, Sprague-DawleyAnalgesicsDrugs, Chinese HerbalFlavonoidsTrpv1 protein, ratTRPV Cation ChannelscapsaicinflavonoidsformaldehydeFreund's adjuvantinflammatory painLongxuejie ()transient receptor potential vanilloid 1

Identifiers

PMID38767627
PMCPMC11077159

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.