Evidence map›Paper›PMID 38767625›Full record

SynthesisJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2024

Efficacy of substances containing 3 types of active ingredients-saponins, flavones, and alkaloids in regulation of cytokines in autoimmune diseases a systematic review and Meta-analysis based on animal studies.

Zhu Ruifang, Zhang Jun, Lyu Yaru, Chen Yulu, Han Shifan, Wang Hongwei

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhu RuifangKey Laboratory for Molecular Diagnosis and Treatment of Hematologic Diseases, Second Hospital of Shanxi Medical University, Shanxi 030001, China.
Zhang JunSchool of Nursing, Shanxi Medical University, Shanxi 030001, China.
Lyu YaruSchool of Nursing, Shanxi Medical University, Shanxi 030001, China.
Chen YuluSchool of Nursing, Shanxi Medical University, Shanxi 030001, China.
Han ShifanEditorial Office, First Hospital of Shanxi Medical University, Shanxi 030001, China.
Wang HongweiKey Laboratory for Molecular Diagnosis and Treatment of Hematologic Diseases, Second Hospital of Shanxi Medical University, Shanxi 030001, China.

Funding

Doctor Starting Foundation of First Hospital of Shanxi Medical University: Material Basis and Mechanism of Codonopsis Pilosula for Preventing and Treating Immune Thrombocytopenia YB2203Fundamental Research Program of Shanxi Province: to Explore the Material Basis and Mechanism of Codonopsis Pilosula for Preventing and Treating Immune Thrombocytopenia based on Network Pharmacology and Molecular Docking 202203021221251
6 · The paper itself

Abstract

objectiveTo investigate the efficacy of substances containing 3 types of active ingredients-saponins, flavones, and alkaloids on experimental animals with autoimmune diseases (AIDs).

methodsThe protocol for this systematic review and Meta-analysis was prospectively registered with PROSPERO (CRD42023395741). Searches were conducted in the China National Knowledge Infrastructure, Wanfang, Chinese Science and Technology Journals, China Biomedical, PubMed, Cochrane Library, and Embase databases to screen for animal studies investigating the therapeutic effects of saponins, flavones, or alkaloids on autoimmune diseases; consequently, corresponding data extraction tables were prepared. Systematic Review Centre for Laboratory Animal Experimentation was used to assess the risk of methodological bias in the included literature. RevMan 5.4 was used for the Meta-analysis on the 8 serum cytokines.

resultsA total of 31 studies were included, all of which were randomized controlled studies. Meta-analysis indicated that substances rich in saponins, flavones, and alkaloids reduced serum levels of interleukin (IL)-1β [standardized mean difference ( CONCLUTIONS: Substances containing saponins, flavones, and alkaloids regulated the changes of immune-related cytokines, it may be a novel dietary substance to relieve and control autoimmune diseases in the future.

Indexed as

AlkaloidsAutoimmune DiseasesCytokinesDrugs, Chinese HerbalFlavonesSaponinsAnimalsHumansAlkaloidsCytokinesDrugs, Chinese HerbalFlavonesSaponinsalkaloidsautoimmune diseasesflavonesMeta-analysissaponinssystem evaluation

Identifiers

PMID38767625
PMCPMC11077143

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.