ArticleCancer reports (Hoboken, N.J.)2024
Treatment intensity affects immune reconstitution even after childhood cancer not treated with hematopoietic stem cell transplantation.
Article in Cancer reports (Hoboken, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A Personalised Vaccination Program Based on Immune Reconstitution in Paediatric Cancer Survivors.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- B Cell Aplasia Following CAR T Cell Therapy: Incidence, Kinetics, Prognostic Implications, and Clinical Management.Cancers · 2026Review
- Incidence of preexisting B-cell aplasia in B-ALL: implications for post-CAR T-cell monitoring.Blood advances · 2024Article
- Treatment intensity affects immune reconstitution even after childhood cancer not treated with hematopoietic stem cell transplantation.Cancer reports (Hoboken, N.J.) · 2024Article
- The Influence of Music Therapy on the Mood State and Hope Level of Patients with Leukemia Complicated with Anxiety Disorder.Noise & healthArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundOnly a few previous studies examine immune system recovery after completed cancer treatment.
aimsThe aim of this study was to analyze immune reconstitution after childhood cancer therapy in a non-hematopoietic stem cell transplantation setting. METHODS AND
resultsWe analyzed children (N = 79) who received chemotherapy with/without irradiation for cancer diagnosed between 2014 and 2019 at Turku University Hospital, Finland. We retrospectively collected data on baseline parameters and post-treatment immunological recovery, namely neutrophil and lymphocyte counts, IgG levels, CD19, CD4 and natural killer cell counts. Immunological parameters were followed until their normalization. Treatment intensity was stratified according to the Intensity of Treatment Rating Scale (ITR-3). We analyzed the effects of treatment intensity on normalization of immunological parameters across the entire treatment range. Treatment intensity had a major effect on immune system recovery after completion of treatment. Most patients had normal immunological parameters 1-4 months post-treatment both in high- and low-intensity treatment groups, but patients classified in the high-intensity group had low parameters more often than patients in the low-intensity group.
conclusionOur data suggest a fast recovery of studied immunological parameters after the majority of current pediatric oncologic treatments. Treatment for high-risk acute lymphoblastic leukemia, acute myeloid leukemia, medulloblastoma, and mature B-cell lymphoma was associated with prolonged recovery times for a substantial proportion of cases. High treatment intensity was associated with prolonged immunological recovery.
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