Evidence map›Paper›PMID 38767446›Full record

ReviewKorean circulation journal2024

Frailty, Sarcopenia, Cachexia, and Malnutrition in Heart Failure.

Daichi Maeda, Yudai Fujimoto, Taisuke Nakade, Takuro Abe, Shiro Ishihara, Kentaro Jujo, Yuya Matsue

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Korean circulation journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07510035 (A Cross-Sectional Observational Study：Prevalence and Associated Factors of Frailty in Hospitalized Elderly Patients With Heart Failure), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07510035 completednot on this map

A Cross-Sectional Observational Study：Prevalence and Associated Factors of Frailty in Hospitalized Elderly Patients With Heart Failure

TypeobservationalSponsorZhejiang HospitalRan2023 to 2023Enrolled298ConditionsElderly Inpatients, Frail, Heart Failure Hospitalization, CGA
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daichi MaedaDepartment of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0001-5438-3500
Yudai FujimotoDepartment of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0009-0004-8286-3228
Taisuke NakadeDepartment of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0002-9491-3286
Takuro AbeDepartment of Cardiology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.ORCID https://orcid.org/0000-0002-8870-9270
Shiro IshiharaDepartment of Cardiology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.ORCID https://orcid.org/0009-0000-9170-4326
Kentaro JujoDepartment of Cardiology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.ORCID https://orcid.org/0000-0002-2011-8204
Yuya MatsueDepartment of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. yuya8950@gmail.com.ORCID https://orcid.org/0000-0003-2456-8525

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With global aging, the number of patients with heart failure has increased markedly. Heart failure is a complex condition intricately associated with aging, organ damage, frailty, and cognitive decline, resulting in a poor prognosis. The relationship among frailty, sarcopenia, cachexia, malnutrition, and heart failure has recently received considerable attention. Although these conditions are distinct, they often exhibit a remarkably close relationship. Overlapping diagnostic criteria have been observed in the recently proposed guidelines and position statements, suggesting that several of these conditions may coexist in patients with heart failure. Therefore, a comprehensive understanding of these conditions is essential, and interventions must not only target these conditions individually, but also provide comprehensive management strategies. This review article provides an overview of the epidemiology, diagnostic methods, overlap, and prognosis of frailty, sarcopenia, cachexia, and malnutrition in patients with heart failure, incorporating insights from the FRAGILE-HF study data. Additionally, based on existing literature, this article discusses the impact of these conditions on the effectiveness of guideline-directed medical therapy for patients with heart failure. While recognizing these conditions early and promptly implementing interventions may be advantageous, further data, particularly from well-powered, large-scale, randomized controlled trials, are necessary to refine personalized treatment strategies for patients with heart failure.

Indexed as

CachexiaFrailtyHeart failureMalnutritionSarcopenia

Identifiers

PMID38767446
PMCPMC11252634

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.