Evidence map›Paper›PMID 38767353›Full record

ArticlemBio2024

mTOR signaling is required for phagocyte free radical production, GLUT1 expression, and control of

Christopher J Genito, Benjamin P Darwitz, Callista P Reber, Nathaniel J Moorman, Christina L Graves, Andrew J Monteith, Lance R Thurlow

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christopher J GenitoDivision of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-9044-964X
Benjamin P DarwitzDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-0936-384X
Callista P ReberDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.
Nathaniel J MoormanDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Christina L GravesDivision of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Andrew J MonteithDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.
Lance R ThurlowDivision of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0003-1839-2922

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
BASIC MICROBIOLOGY &INFECTIOUS DISEASEST32AI007110 · NIAID · UNIVERSITY OF FLORIDA · PI Stephanie M Karst · 1985 to 2026
$4.3M
Diabetes and Antibiotic Treatment FailureR01AI173004 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Brian Patrick Conlon, Lance R. Thurlow · 2023 to 2026
$2.8M
HHS | NIH | NIAID | Division of Intramural Research (DIR, NIAID) R01AI173004NCI NIH HHS P30 CA016086NIAID NIH HHS R01 AI173004
6 · The paper itself

Abstract

Mammalian target of rapamycin (mTOR) is a key regulator of metabolism in the mammalian cell. Here, we show the essential role for mTOR signaling in the immune response to bacterial infection. Inhibition of mTOR during infection with

Indexed as

Glucose Transporter Type 1PhagocytesSignal TransductionStaphylococcal InfectionsStaphylococcus aureusTOR Serine-Threonine KinasesAnimalsFree RadicalsHumansMiceMice, Inbred C57BLFree RadicalsGlucose Transporter Type 1MTOR protein, humanSLC2A1 protein, humanTOR Serine-Threonine Kinasesimmune dysfunctionmTORStaphylococcus aureus

Identifiers

PMID38767353
PMCPMC11324022

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.