Evidence map›Paper›PMID 38767308›Full record

ArticleEuropean journal of translational myology2024

Botulinum toxin in the rehabilitation of painful syndromes: multiperspective literature analysis, lexical analysis and systematic review of randomized controlled trials.

Daniele Coraci, Maria Chiara Maccarone, Lisa Ragazzo, Lucrezia Tognolo, Domenico Antonio Restivo, Gabriele Santilli, Ana Lucila Moreira, Paola Emilia Ferrara, Gianpaolo Ronconi, Stefano Masiero

Abstract read
In one paragraph

Article in European journal of translational myology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniele CoraciDepartment of Neuroscience, Section of Rehabilitation, University of Padova, Padua. danielecoraci@aol.com.
Maria Chiara MaccaroneDepartment of Neuroscience, Section of Rehabilitation, University of Padova, Padua. mariachiara.maccarone93@gmail.com.
Lisa RagazzoDepartment of Neuroscience, Section of Rehabilitation, University of Padova, Padua. lisa.ragazzo@unipd.it.
Lucrezia TognoloDepartment of Neuroscience, Section of Rehabilitation, University of Padova, Padua. lucrezia.tognolo@unipd.it.
Domenico Antonio RestivoDepartment of Clinical and Experimental Medicine, University of Messina, Messina. domenicoantonio.restivo@unime.it.
Gabriele SantilliDepartment of Anatomical, Histological and Legal Medical Sciences and Science of the Locomotor System, Rome. gabriele.santilli@uniroma1.it.
Ana Lucila MoreiraDepartment of Neurology, Faculdade de Medicina da Universidade de São Paulo, São Paulo. ana.lucila.moreira@hotmail.com.
Paola Emilia FerraraFondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome. paolaemilia.ferrara@policlinicogemelli.it.
Gianpaolo RonconiFondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome. gianpaolo.ronconi@policlinicogemelli.it.
Stefano MasieroDepartment of Neuroscience, Section of Rehabilitation, University of Padova, Padua. stef.masiero@unipd.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pain represents a common symptom of several diseases and is often associated with a reduction in rehabilitation outcomes and recovery. The effectiveness of pain alleviation by botulinum toxin has been recently demonstrated. We searched in PubMed the papers about this topic published in the last ten years, and we selected clinical trials, guidelines, meta-analyses, reviews, and systematic reviews. We used different approaches: multiperspective presentation, lexical evaluation, and systematic review. The systematic review was only performed for the randomized controlled trials. We predominantly found reviews and trials about the rehabilitation of stroke/brain injury and epicondylitis. The most common outcome measures were pain, function, and spasticity. Among the common words, pain was the most frequent and the terms were grouped into different families, especially concerning the outcomes. Rehabilitation showed a relatively low frequency. Finally, the systematic review showed moderate-low levels of bias which confirms the effectiveness of botulinum toxin for pain treatment. The current literature about botulinum toxin is wide and globally diffuse but with some limitations in study strategies and clearness in the formal presentation. The evidence justifies the use of botulinum toxin in treating pain in different diseases.

Identifiers

PMID38767308
PMCPMC11264230

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.