Evidence map›Paper›PMID 38766767›Full record

ArticleAmerican journal of physiology. Cell physiology2024

mTORC1 and BMP-Smad1/5 regulation of serum-stimulated myotube hypertrophy: a role for autophagy.

Quan Zhang, Jessica L Halle, Brittany R Counts, Min Pi, James A Carson

Abstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Quan ZhangIntegrative Muscle Biology Laboratory, Division of Rehabilitation Sciences, College of Health ProfessionsUniversity of Tennessee Health Science Center, Memphis, Tennessee, United States.ORCID 0000-0001-6028-6977
Jessica L HalleIntegrative Muscle Biology Laboratory, Division of Rehabilitation Sciences, College of Health ProfessionsUniversity of Tennessee Health Science Center, Memphis, Tennessee, United States.ORCID 0000-0002-3174-5713
Brittany R CountsIntegrative Muscle Biology Laboratory, Division of Rehabilitation Sciences, College of Health ProfessionsUniversity of Tennessee Health Science Center, Memphis, Tennessee, United States.
Min PiDepartment of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States.
James A CarsonHuffines Institute for Sports Medicine & Human Performance, Department of Kinesiology & Sports Management , Texas A&M University, College Station, Texas, United States.ORCID 0000-0003-3733-8796

Funding

Muscle GPRC6A regulation of protein turnover with overload and disuse recoveryR21AR079843 · NIAMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI ALWAY, STEPHEN E, PI, MIN · 2022 to 2023
$373k
HHS | NIH | National Cancer Institute (NCI) R21 AR079843-01A1NIAMS NIH HHS R21 AR079843
6 · The paper itself

Abstract

Protein synthesis regulation is critical for skeletal muscle hypertrophy, yet other established cellular processes are necessary for growth-related cellular remodeling. Autophagy has a well-acknowledged role in muscle quality control, but evidence for its role in myofiber hypertrophy remains equivocal. Both mammalian target of rapamycin complex I (mTORC1) and bone morphogenetic protein (BMP)-Smad1/5 (Sma and Mad proteins from

Indexed as

AutophagyHypertrophyMechanistic Target of Rapamycin Complex 1Muscle Fibers, SkeletalSignal TransductionAnimalsBone Morphogenetic ProteinsCell DifferentiationCell LineMiceSerumSmad1 ProteinSmad5 ProteinBone Morphogenetic ProteinsMechanistic Target of Rapamycin Complex 1Smad1 ProteinSmad1 protein, mouseSmad5 ProteinSmad5 protein, mouseC2C12 myotubescell growthprotein synthesisrapamycin

Identifiers

PMID38766767
PMCPMC11371323

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.