Evidence map›Paper›PMID 38766653›Full record

ArticleCurrent research in structural biology2024

GraSp-PSN: A web server for graph spectra based analysis of protein structure networks.

Vasundhara Gadiyaram, Vasam Manjveekar Prabantu, Arinnia Anto Manjaly, Ananth Muthiah, Saraswathi Vishveshwara

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Article in Current research in structural biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Vasundhara GadiyaramMolecular Biophysics Unit, Indian Institute of Science, Bangalore, India.
Vasam Manjveekar PrabantuMolecular Biophysics Unit, Indian Institute of Science, Bangalore, India.
Arinnia Anto ManjalyMolecular Biophysics Unit, Indian Institute of Science, Bangalore, India.
Ananth MuthiahMolecular Biophysics Unit, Indian Institute of Science, Bangalore, India.
Saraswathi VishveshwaraMolecular Biophysics Unit, Indian Institute of Science, Bangalore, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The function of a protein is most of the time achieved due to minute conformational changes in its structure due to ligand binding or environmental changes or other interactions. Hence the analysis of structure of proteins should go beyond the analysis of mere atom contacts and should include the emergent global structure as a whole. This can be achieved by graph spectra based analysis of protein structure networks. GraSp-PSN is a web server that can assist in (1) acquiring weighted protein structure network (PSN) and network parameters ranging from atomic level to global connectivity from the three dimensional coordinates of a protein, (2) generating scores for comparison of a pair of protein structures with detailed information of local to global connectivity, and (3) assigning perturbation scores to the residues and their interactions, that can prioritise them in terms of residue clusters. The methods implemented in the server are generic in nature and can be used for comparing networks in any discipline by uploading adjacency matrices in the server. The webserver can be accessed using the following link: https://pople.mbu.iisc.ac.in/.

Indexed as

Backbone networkEigen valuesEigen vectorsGraph spectral analysisGraph spectral comparisonNetwork perturbationNetwork similarity scoreProtein structure networksSide chain network

Identifiers

PMID38766653
PMCPMC11098725

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