Evidence map›Paper›PMID 38766487›Full record

ArticlePeerJ2024

Arsenic disulfide promoted the demethylation of

Chen Chen, Ling Wang, Yan Liu, Shenghong Du, Qingliang Teng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chen Chen *Department of Hematology, The Affiliated Taian City Central Hospital of Qingdao University, Taian, Shandong, China.
Ling Wang *Department of Hematology, The Affiliated Taian City Central Hospital of Qingdao University, Taian, Shandong, China.
Yan LiuDepartment of Breast Surgery, The Affiliated Taian City Central Hospital of Qingdao University, Taian, Shandong, China.
Shenghong DuDepartment of Hematology, The Affiliated Taian City Central Hospital of Qingdao University, Taian, Shandong, China.
Qingliang TengDepartment of Hematology, The Affiliated Taian City Central Hospital of Qingdao University, Taian, Shandong, China.

Funding

Taian Science and Technology Development Guiding Project
6 · The paper itself

Abstract

Background: Promoter hypermethylation of the tumor suppressor gene is one of the well-studied causes of cancer development. The drugs that reverse the process by driving demethylation could be a candidate for anticancer therapy. This study was designed to investigate the effects of arsenic disulfide on Methods: We knocked down the expression of Results: Conclusion: Experimental evidence shows that

Indexed as

ArsenicalsDNA MethylationLymphoma, Large B-Cell, DiffuseCell Line, TumorCell ProliferationDisulfidesDNA-Binding ProteinsDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3BGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansPromoter Regions, GeneticArsenicalsDisulfidesDNA-Binding ProteinsDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3BDNMT1 protein, humanMBD2 protein, humanArsenic disulfideDemethylationDiffuse large B cell lymphomaDNMTsMBD2

Identifiers

PMID38766487
PMCPMC11100478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.