Evidence map›Paper›PMID 38766421›Full record

ArticleWorld journal of diabetes2024

Disparate outcomes in Hispanic patients with metabolic dysfunction-associated steatotic liver disease/steatohepatitis and type 2 diabetes: Large cohort study.

Joseph Matthew Gosnell, George Golovko, Esteban Arroyave, Akshata Moghe, Michael L Kueht, Omar Abdul Saldarriaga, Kevin H McKinney, Heather L Stevenson, Monique R Ferguson

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In one paragraph

Article in World journal of diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joseph Matthew GosnellDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, United States. jogosnel@utmb.edu.
George GolovkoDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX 77555, United States.
Esteban ArroyaveDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, United States.
Akshata MogheDepartment of Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, United States.
Michael L KuehtDepartment of Surgery, University of Texas Medical Branch, Galveston, TX 77555, United States.
Omar Abdul SaldarriagaCenter for Tropical Diseases, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, United States.
Kevin H McKinneyDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, United States.
Heather L StevensonDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, United States.
Monique R FergusonDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, United States.

Funding

ANALYSIS OF INTRAHEPATIC MACROPHAGE PROFILES FOR PREDICTING RISK OF FIBROSIS DEVELOPMENT IN PATIENTS WITH DIFFERENT TYPES OF CHRONIC LIVER DISEASER01DK125730 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI STEVENSON, HEATHER L · 2021 to 2025
$2.5M
NIDDK NIH HHS R01 DK125730
6 · The paper itself

Abstract

backgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are a growing health burden across a significant portion of the global patient population. However, these conditions seem to have disparate rates and outcomes between different ethnic populations. The combination of MASLD/MASH and type 2 diabetes increases the risk of hepatocellular carcinoma (HCC), and Hispanic patients experience the greatest burden, particularly those in South Texas.

aimTo compare outcomes between Hispanic and non-Hispanic patients in the United States, while further focusing on the Hispanic population within Southeast Texas to determine whether the documented disparity in outcomes is a function of geographical circumstance or if there is a more widespread reason that all clinicians must account for in prognostic consideration.

methodsThis cohort analysis was conducted with data obtained from TriNetX, LLC ("TriNetX"), a global federated health research network that provides access to deidentified medical records from healthcare organizations worldwide. Two cohort networks were used: University of Texas Medical Branch (UTMB) hospital and the United States national database collective to determine whether disparities were related to geographic regions, like Southeast Texas.

resultsThis study findings revealed Hispanics/Latinos have a statistically significant higher occurrence of HCC, type 2 diabetes mellitus, and liver fibrosis/cirrhosis in both the United States and the UTMB Hispanic/Latino groups. All-cause mortality in Hispanics/Latinos was lower within the United States group and not statistically elevated in the UTMB cohort.

conclusionThis would appear to support that Hispanic patients in Southeast Texas are not uniquely affected compared to the national Hispanic population.

Indexed as

Diabetes mellitusHepatocellular carcinomaHispanicMetabolic dysfunction-associated steatohepatitisMetabolic dysfunction-associated steatotic liver diseaseNon-alcoholic fatty liver diseaseNon-alcoholic steatohepatitisSteatotic liver diseaseTriNetX

Identifiers

PMID38766421
PMCPMC11099377

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.