Evidence map›Paper›PMID 38766329›Full record

ArticleInternational journal of ophthalmology2024

Systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio in patients with type 2 diabetes at different stages of diabetic retinopathy.

Ying Gao, Rong-Xin Lu, Yun Tang, Xin-Yi Yang, Hu Meng, Chang-Lin Zhao, Yi-Lu Chen, Feng Yan, Qian Cao

Abstract read
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In one paragraph

Article in International journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  8. [Neutrophil-lymphocyte ratio and retinopathy in patients with type 2 diabetes mellitus].Revista medica del Instituto Mexicano del Seguro Social · 2026
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  15. The Mechanisms of Inflammatory Factors and the Total Load of Cerebral Small Vessel Disease in Diabetic Retinopathy and Cognitive Impairment.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ying GaoDepartment of Ophthalmology, Sir Run Run Hospital, Nanjing Medical University, Nanjing 211112, Jiangsu Province, China.
Rong-Xin LuDepartment of Thoracic Surgery, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Yun TangMedical School, Nanjing University, Nanjing 210093, Jiangsu Province, China.
Xin-Yi YangDepartment of Ophthalmology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
Hu MengDepartment of Ophthalmology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
Chang-Lin ZhaoDepartment of Ophthalmology, Sir Run Run Hospital, Nanjing Medical University, Nanjing 211112, Jiangsu Province, China.
Yi-Lu ChenDepartment of Ophthalmology, Sir Run Run Hospital, Nanjing Medical University, Nanjing 211112, Jiangsu Province, China.
Feng YanDepartment of Ophthalmology, Taikang Xianlin Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210046, Jiangsu Province, China.
Qian CaoDepartment of Ophthalmology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) levels in patients with type 2 diabetes at different stages of diabetic retinopathy (DR).

methodsThis retrospective study included 141 patients with type 2 diabetes mellitus (DM): 45 without diabetic retinopathy (NDR), 47 with non-proliferative diabetic retinopathy (NPDR), and 49 with proliferative diabetic retinopathy (PDR). Complete blood counts were obtained, and NLR, PLR, and SII were calculated. The study analysed the ability of inflammatory markers to predict DR using receiver operating characteristic (ROC) curves. The relationships between DR stages and SII, PLR, and NLP were assessed using multivariate logistic regression.

resultsThe average NLR, PLR, and SII were higher in the PDR group than in the NPDR group (

conclusionThe NLR, PLR, and SII may be used as predictors of DR.

Indexed as

diabetic retinopathyneutrophil-to-lymphocyte ratioplatelet-to-lymphocyte ratiosystemic immune-inflammation index

Identifiers

PMID38766329
PMCPMC11074207

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.