Evidence map›Paper›PMID 38766234›Full record

ArticlebioRxiv : the preprint server for biology2024

An unbiased method to partition diverse neuronal responses into functional ensembles reveals interpretable population dynamics during innate social behavior.

Alexander Lin, Cyril Akafia, Olga Dal Monte, Siqi Fan, Nicholas Fagan, Philip Putnam, Kay M Tye, Steve Chang, Demba Ba, Aza Stephen Allsop

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexander LinSchool of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
Cyril AkafiaDepartment of Psychiatry, Yale University, New Haven, Connecticut, USA.ORCID 0009-0003-0637-8362
Olga Dal MonteDepartment of Psychology, Yale University, New Haven, Connecticut, USA.ORCID 0000-0002-7823-4769
Siqi FanDepartment of Psychology, Yale University, New Haven, Connecticut, USA.ORCID 0000-0003-3101-108X
Nicholas FaganDepartment of Psychology, Yale University, New Haven, Connecticut, USA.
Philip PutnamDepartment of Psychology, Yale University, New Haven, Connecticut, USA.
Kay M TyeSalk Institute for Biological Studies, La Jolla, California, USA.ORCID 0000-0002-2435-0182
Steve ChangDepartment of Psychology, Yale University, New Haven, Connecticut, USA.
Demba BaSchool of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
Aza Stephen AllsopCenter for Collective Healing, Department of Psychiatry and Behavioral Sciences, Howard University, Washington DC, USA.ORCID 0000-0002-0438-3163

Funding

RESEARCH TRAINING - BIOLOGICAL SCIENCEST32MH014276 · NIMH · YALE UNIVERSITY · PI Marina R Picciotto · 1985 to 2026
$7.2M
Clinical Neuroscience Research Training Program in PsychiatryT32MH019961 · NIMH · YALE UNIVERSITY · PI Christopher John Pittenger · 1996 to 2026
$5.9M
Solving the Valence Assignment ProblemR37MH102441 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Kay Maxine Tye · 2021 to 2026
$5.6M
Behavioral and Neural Bases of Combining Oxytocin and Naloxone for Optimally Enhancing Interactive Social AttentionR01MH120081 · NIMH · YALE UNIVERSITY · PI CHANG, STEVE W. C. · 2019 to 2023
$2.7M
Toward A Macaque Model Of Social Brain Dysfunction In Real-Life Social InteractionsR01MH110750 · NIMH · YALE UNIVERSITY · PI CHANG, STEVE W. C. · 2016 to 2020
$2.5M
Decoding ensemble dynamics from cortico-amygdalar circuits during social choiceK08MH134028 · NIMH · YALE UNIVERSITY · PI ALLSOP, AZA STEPHEN · 2023 to 2025
$965k
NIMH NIH HHS K08 MH134028NIMH NIH HHS R01 MH110750NIMH NIH HHS R01 MH120081NIMH NIH HHS R37 MH102441NIMH NIH HHS T32 MH014276NIMH NIH HHS T32 MH019961
6 · The paper itself

Abstract

In neuroscience, understanding how single-neuron firing contributes to distributed neural ensembles is crucial. Traditional methods of analysis have been limited to descriptions of whole population activity, or, when analyzing individual neurons, criteria for response categorization varied significantly across experiments. Current methods lack scalability for large datasets, fail to capture temporal changes and rely on parametric assumptions. There's a need for a robust, scalable, and non-parametric functional clustering approach to capture interpretable dynamics. To address this challenge, we developed a model-based, statistical framework for unsupervised clustering of multiple time series datasets that exhibit nonlinear dynamics into an

Identifiers

PMID38766234
PMCPMC11100741

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.