Evidence map›Paper›PMID 38766202›Full record

ArticlebioRxiv : the preprint server for biology2024

KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency.

Andrew J Devine, Noah J Smith, Rashika Joshi, Brandon Brooks-Patton, Jenna Dunham, Ansley N Varisco, Emily M Goodman, Qiang Fan, Basilia Zingarelli, Brian M Varisco

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Andrew J DevineOhio University Heritage College of Osteopathic Medicine, Athens, OH, USA.
Noah J SmithCollege of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Rashika JoshiCritical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Brandon Brooks-PattonNorthern Kentucky University, Covington, KY, USA.
Jenna DunhamNorthern Kentucky University, Covington, KY, USA.
Ansley N VariscoUniversity of Arkansas at Little Rock, Little Rock, AR, USA.
Emily M GoodmanUniversity of Arkansas for Medical Sciences, Little Rock, AR, USA.
Qiang FanCritical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Basilia ZingarelliCritical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Brian M VariscoOhio University Heritage College of Osteopathic Medicine, Athens, OH, USA.

Funding

PPARgamma and PPARgamma agonists in septic shockR01GM067202 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI ZINGARELLI, BASILIA · 2003 to 2015
$3.9M
AGE-DEPENDENT MECHANISMS OF METABOLIC RECOVERY IN HEMORRHAGIC SHOCKR01GM115973 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI ZINGARELLI, BASILIA · 2015 to 2022
$2.7M
Chymotrypsin-like Elastase 1 in Lung Development and DiseaseR01HL141229 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI ZINGARELLI, BASILIA · 2018 to 2022
$2.6M
NHLBI NIH HHS R01 HL141229NIGMS NIH HHS R01 GM067202NIGMS NIH HHS R01 GM115973
6 · The paper itself

Abstract

Alpha-1 antitrypsin (AAT) deficiency is the most common genetic cause of emphysema. Chymotrypsin-like Elastase 1 (CELA1) is a serine protease neutralized by AAT and is important in emphysema progression.

Indexed as

Alpha-1 Antitrypsinanti-ProteaseCOPDElastaseEmphysemaProtease

Identifiers

PMID38766202
PMCPMC11100728

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.