Evidence map›Paper›PMID 38766193›Full record

ArticlebioRxiv : the preprint server for biology2024

Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening.

Taslima G Khan, Juliana Bragazzi Cunha, Chinmay Raut, Michael Burroughs, Sascha N Goonewardena, Alan V Smrcka, Elizabeth K Speliotes, Brian T Emmer

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Taslima G KhanProgram in Chemical Biology, University of Michigan, Ann Arbor MI.
Juliana Bragazzi CunhaDivision of Hospital Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor MI.ORCID 0000-0002-3493-2960
Chinmay RautDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor MI.
Michael BurroughsDepartment of Pharmacology, University of Michigan, Ann Arbor MI.
Sascha N GoonewardenaDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor MI.
Alan V SmrckaDepartment of Pharmacology, University of Michigan, Ann Arbor MI.
Elizabeth K SpeliotesDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor MI.
Brian T EmmerDivision of Hospital Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor MI.ORCID 0000-0001-7365-1021

Funding

Understanding and Manipulating Phospholipase C and G Protein beta gamma subunit Signaling NetworksR35GM127303 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alan V. Smrcka · 2018 to 2026
$4.8M
Integrative Polygenic Genetic Studies of Non-alcoholic Fatty Liver DiseaseR01DK131787 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPELIOTES, ELIZABETH K · 2022 to 2025
$2.7M
Identification and Characterization of Loci Associated with Non-alcoholic Fatty Liver DiseaseR01DK128871 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ALLRED, NICHOLETTE D., SPELIOTES, ELIZABETH K · 2021 to 2024
$2.6M
Molecular Regulation of LDL Receptor ExpressionR01HL167733 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Brian T Emmer · 2024 to 2026
$1.9M
Cholesterol regulation by the cargo receptor SURF4K08HL148552 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EMMER, BRIAN T · 2019 to 2023
$788k
CSRD VA I01 CX002560NHLBI NIH HHS K08 HL148552NHLBI NIH HHS R01 HL167733NIDDK NIH HHS R01 DK128871NIDDK NIH HHS R01 DK131787NIGMS NIH HHS R35 GM127303
6 · The paper itself

Abstract

An elevated level of lipoprotein(a), or Lp(a), in the bloodstream has been causally linked to the development of atherosclerotic cardiovascular disease and calcific aortic valve stenosis. Steady state levels of circulating lipoproteins are modulated by their rate of clearance, but the identity of the Lp(a) uptake receptor(s) has been controversial. In this study, we performed a genome-scale CRISPR screen to functionally interrogate all potential Lp(a) uptake regulators in HuH7 cells. Strikingly, the top positive and negative regulators of Lp(a) uptake in our screen were

Identifiers

PMID38766193
PMCPMC11100788

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.