Evidence map›Paper›PMID 38766176›Full record

ArticlebioRxiv : the preprint server for biology2024

AAV-mediated genome editing is influenced by the formation of R-loops.

Francesco Puzzo, Magdalena P Crossley, Aranyak Goswami, Feijie Zhang, Katja Pekrun, Jada L Garzon, Karlene A Cimprich, Mark A Kay

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Francesco PuzzoDepartment of Genetics, Stanford University, Stanford, CA.
Magdalena P CrossleyDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA.
Aranyak GoswamiDepartment of Genetics, Stanford University, Stanford, CA.
Feijie ZhangDepartment of Genetics, Stanford University, Stanford, CA.
Katja PekrunDepartment of Genetics, Stanford University, Stanford, CA.
Jada L GarzonDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA.
Karlene A CimprichDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA.
Mark A KayDepartment of Genetics, Stanford University, Stanford, CA.ORCID 0000-0002-2799-2615

Funding

Transcription-Associated Genome InstabilityR01GM119334 · NIGMS · STANFORD UNIVERSITY · PI Karlene A Cimprich · 2016 to 2026
$4.0M
Molecular Pharmacology Training ProgramT32GM136631 · NIGMS · STANFORD UNIVERSITY · PI BOGYO, MATTHEW, CHEN, JAMES K · 2021 to 2025
$2.0M
BINDING OF MTP TO APOB DURING LIPOPROTEIN ASSEMBLYR01HL064272 · NHLBI · SUNY DOWNSTATE MEDICAL CENTER · PI HUSSAIN, M MAHMOOD · 1999 to 2006
$1.8M
High Throughput DNA Sequencer UpgradeS10OD018220 · OD · STANFORD UNIVERSITY · PI COLLER, JOHN · 2014 to 2014
$596k
Computer ClusterS10OD021763 · OD · STANFORD UNIVERSITY · PI JI, HANLEE P · 2016 to 2016
$481k
NHLBI NIH HHS R01 HL064272NIGMS NIH HHS R01 GM119334NIGMS NIH HHS T32 GM136631NIH HHS S10 OD018220NIH HHS S10 OD021763
6 · The paper itself

Abstract

Recombinant adeno-associated viral vectors (rAAV) hold an intrinsic ability to stimulate homologous recombination (AAV-HR) and are the most used in clinical settings for

Identifiers

PMID38766176
PMCPMC11100726

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.