Evidence map›Paper›PMID 38766154›Full record

ArticlebioRxiv : the preprint server for biology2024

Negative Selection Allows DNA Mismatch Repair-Deficient Mouse Fibroblasts

Lei Zhang, Moonsook Lee, Xiaoxiao Hao, Joseph Ehlert, Zhongxuan Chi, Bo Jin, Alexander Y Maslov, Albert-László Barabási, Jan H J Hoeijmakers, Winfried Edelmann and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lei ZhangInstitute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN 55455, USA.
Moonsook LeeDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Xiaoxiao HaoDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Joseph EhlertNetwork Science Institute, Northeastern University, Boston, MA, USA.
Zhongxuan ChiDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bo JinDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Alexander Y MaslovDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Albert-László BarabásiNetwork Science Institute, Northeastern University, Boston, MA, USA.
Jan H J HoeijmakersDepartment of Molecular Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Winfried EdelmannDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Jan VijgDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Xiao DongInstitute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-9987-5760

Funding

THE IMPACT OF CELLULAR DEFENSE ON THE ROLE OF Ku80 IN GENOME MAINTENANCE AND LONGP01AG017242 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI VIJG, JAN · 1999 to 2023
$46.1M
The role of hyaluronan in longevity and cancer resistance of longest-lived rodentP01AG047200 · NIA · UNIVERSITY OF ROCHESTER · PI Andrei Seluanov · 2014 to 2026
$36.9M
Validation and characterization of the identified variants associated with human longevity in mouse modelsU19AG056278 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI NIR J BARZILAI, Paul D. Robbins · 2017 to 2026
$24.5M
Project 3 - Role of Proline Metabolism in Regulation of Mammalian Cardiomyocyte ProliferationP01HL160476 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Jianyi Zhang · 2022 to 2026
$13.1M
The role of senescent cells in dysregulating immune responses and pathogen controlP01AI172501 · NIAID · UNIVERSITY OF MINNESOTA · PI DAVID MASOPUST · 2024 to 2026
$10.9M
Einstein's Nathan Shock Center of Excellence in Basic Biology of AgingP30AG038072 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HUFFMAN, DEREK MAJOR · 2010 to 2024
$10.8M
Cross-Validation of Genome Integrity Assays in Primary Human CellsU01ES029519 · NIEHS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SPIVACK, SIMON D, VIJG, JAN · 2018 to 2022
$3.6M
Integrative, age-related changes in genome and epigenome in human lung in relation to smokingU01HL145560 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SPIVACK, SIMON D, VIJG, JAN · 2019 to 2022
$2.6M
Computational evaluation of the causal role of somatic mutations in human agingR00AG056656 · NIA · UNIVERSITY OF MINNESOTA · PI DONG, XIAO · 2021 to 2023
$747k
NHLBI NIH HHS P01 HL160476NHLBI NIH HHS U01 HL145560NIAID NIH HHS P01 AI172501NIA NIH HHS P01 AG017242NIA NIH HHS P01 AG047200NIA NIH HHS P30 AG038072NIA NIH HHS R00 AG056656NIA NIH HHS U19 AG056278NIEHS NIH HHS U01 ES029519
6 · The paper itself

Abstract

Substantial numbers of somatic mutations have been found to accumulate with age in different human tissues. Clonal cellular amplification of some of these mutations can cause cancer and other diseases. However, it is as yet unclear if and to what extent an increased burden of random mutations can affect cellular function without clonal amplification. We tested this in cell culture, which avoids the limitation that an increased mutation burden

Indexed as

AgingDNA mismatch repair deficiencyMutational signatureMutation burdenSingle-cell whole-genome sequencing

Identifiers

PMID38766154
PMCPMC11100588

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.