Evidence map›Paper›PMID 38766097›Full record

ArticlebioRxiv : the preprint server for biology2024

Repeat modules and N-linked glycans define structure and antigenicity of a critical enterotoxigenic

Zachary T Berndsen, Marjahan Akhtar, Mahima Thapa, Tim Vickers, Aaron Schmitz, Jonathan L Torres, Sabyasachi Baboo, Pardeep Kumar, Nazia Khatoom, Alaullah Sheikh and 13 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Zachary T BerndsenDepartment of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA, USA.ORCID 0000-0003-4531-9907
Marjahan AkhtarDepartment of Medicine, Division of Infectious Diseases, Washington University in Saint Louis, School of Medicine. Saint Louis, Missouri, USA.ORCID 0000-0001-8316-9191
Mahima ThapaDepartment of Pathology and Immunology, Washington University in Saint Louis, School of Medicine. Saint Louis, Missouri, USA. Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St Louis, MO, USA and The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, MO, USA.ORCID 0009-0006-8953-1677
Tim VickersDepartment of Medicine, Division of Infectious Diseases, Washington University in Saint Louis, School of Medicine. Saint Louis, Missouri, USA.ORCID 0000-0003-4885-1798
Aaron SchmitzDepartment of Pathology and Immunology, Washington University in Saint Louis, School of Medicine. Saint Louis, Missouri, USA. Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St Louis, MO, USA and The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-8077-6751
Jonathan L TorresDepartment of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA, USA.ORCID 0000-0003-0137-8497
Sabyasachi BabooDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0002-4547-5160
Pardeep KumarDepartment of Medicine, Division of Infectious Diseases, Washington University in Saint Louis, School of Medicine. Saint Louis, Missouri, USA.ORCID 0009-0008-4313-6270
Nazia KhatoomDepartment of Medicine, Division of Infectious Diseases, Washington University in Saint Louis, School of Medicine. Saint Louis, Missouri, USA.ORCID 0000-0001-8238-9782
Alaullah SheikhDepartment of Medicine, Division of Infectious Diseases, Washington University in Saint Louis, School of Medicine. Saint Louis, Missouri, USA.ORCID 0000-0002-2972-6978
Melissa HamrickDepartment of Medicine, Division of Infectious Diseases, Washington University in Saint Louis, School of Medicine. Saint Louis, Missouri, USA.ORCID 0000-0001-8620-962X
Jolene K DiedrichDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0001-6489-4558
Salvador Martinez-BartolomeDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0001-7592-5612
Patrick T GarrettDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0002-8434-9693
John R YatesDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0001-5267-1672
Jackson S TurnerDepartment of Pathology and Immunology, Washington University in Saint Louis, School of Medicine. Saint Louis, Missouri, USA. Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St Louis, MO, USA and The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-4396-6265
Renee M LairdOperationally Relevant Infections Department, Naval Medical Research Command (NMRC), Silver Spring, Maryland, USA.ORCID 0000-0002-0559-4114
Frédéric PolyOperationally Relevant Infections Department, Naval Medical Research Command (NMRC), Silver Spring, Maryland, USA.ORCID 0000-0003-0887-2084
Chad K PorterNaval Medical Research Command (NMRC), Silver Spring, Maryland, USA.ORCID 0000-0001-7258-1690
Jeffrey CoppsDepartment of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA, USA.ORCID 0000-0003-4793-7258
Ali H EllebedyDepartment of Pathology and Immunology, Washington University in Saint Louis, School of Medicine. Saint Louis, Missouri, USA. Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St Louis, MO, USA and The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-6129-2532
Andrew B WardDepartment of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA, USA.ORCID 0000-0001-7153-3769
James M FleckensteinDepartment of Medicine, Division of Infectious Diseases, Washington University in Saint Louis, School of Medicine. Saint Louis, Missouri, USA.ORCID 0000-0002-1148-697X

Funding

Infectious Diseases/Basic Microbial Pathogenic MechanismsT32AI007172 · NIAID · WASHINGTON UNIVERSITY · PI Daniel E. Goldberg, JENNIFER A PHILIPS · 1985 to 2026
$13.0M
Novel Antigen Identification for an Enterotoxigenic E. coli VaccineR01AI089894 · NIAID · WASHINGTON UNIVERSITY · PI Zachary T. Berndsen, James Michael Fleckenstein · 2010 to 2026
$7.4M
Molecular Microbiology of Enterotoxigenic E. coli Pathogen-Host InteractionsR01AI126887 · NIAID · WASHINGTON UNIVERSITY · PI FLECKENSTEIN, JAMES MICHAEL · 2016 to 2020
$1.6M
Molecular Pathogenesis of Enterotoxigenic Escherichia coli InfectionsI01BX001469 · VA · ST. LOUIS VA MEDICAL CENTER · PI FLECKENSTEIN, JAMES MICHAEL · 2013 to 2017
–
BLRD VA I01 BX001469NIAID NIH HHS R01 AI089894NIAID NIH HHS R01 AI126887NIAID NIH HHS T32 AI007172
6 · The paper itself

Abstract

Enterotoxigenic

Identifiers

PMID38766097
PMCPMC11100705

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.