ArticlebioRxiv : the preprint server for biology2024
L-Dopa induced dyskinesias require Cholinergic Interneuron expression of Dopamine 2 receptor.
Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Striatal Cholinergic Interneurons (CIN) are drivers of L-Dopa induced Dyskinesias (LID). However, what signaling pathways elicit aberrant CIN activity remains unclear. CIN express D2 and D5 receptors suggesting repeated activation of these receptors in response to L-Dopa could promote LID. While the role of D5 in this process has recently been probed, little is known about the role of D2. Method: Mice with CIN-specific D2 ablation (D2 Results: D2 Conclusion: The activation of D2 specifically on CIN is a key driver of LID.
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