Evidence map›Paper›PMID 38765909›Full record

ArticleClinical and experimental hepatology2024

The association of oxidative stress of neonatal hyperbilirubinemia and vitamin E supplementation.

Mohamed Zaeim Hafez Ahmed, Reham Helmy Amin Helmy Saad, Ahmad Gadalla, Ramadan Hassan Ibrahim Thabet, Ahmed Abdrabo Elshenawy Elsisi, Ahmed Abdel Nasser Ahmed Mohamed, Mohamed Gaber Abdallah, Tarek Shikhon, Hussien Eleimy Hussien Mohmmed Maged, Muhammad Abdelbaeth Hassan Elfiky and 3 more

Abstract read
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Article in Clinical and experimental hepatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Antioxidant efficacy ofAvicenna journal of phytomedicine · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mohamed Zaeim Hafez AhmedPhysiology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Reham Helmy Amin Helmy SaadPediatrician specialist registrar, M.Sc., Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ahmad GadallaPhysiology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Ramadan Hassan Ibrahim ThabetPharmacology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Ahmed Abdrabo Elshenawy ElsisiPharmacology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Ahmed Abdel Nasser Ahmed MohamedPharmacology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Mohamed Gaber AbdallahBiochemistry Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Tarek ShikhonBiochemistry Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Hussien Eleimy Hussien Mohmmed MagedPediatric specialist, Fujariah, Fujariah city, United Arab of Emirates.
Muhammad Abdelbaeth Hassan ElfikyPhysiology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Marwa Fekry HassanCommunity and Public Health Department, National Liver Institute, Menoufia University, Shebin elkom, Menoufia, Egypt.
Fatma Mahmoud AbdelraheemHistology and Cell Biology Department, Fuculty of Medicine, Assiut University, Assiut, Egypt.
Ghada Adel HegazyClinical Pharmacology Department, Faculty of Medicine, Menoufia University, Shebin elkom, Menoufia, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim of the study: Jaundice in newborns is a sign of skin and sclera pigmentation. Hyperbilirubinemia and these phenomena do, however, have a relationship. According to many clinical studies, elevated blood bilirubin and low vitamin E (VE) levels in newborns are associated. The aim of the study was to investigate the association of oxidative stress of neonatal hyperbilirubinemia in patients who underwent phototherapy with additional vitamin E supplementation (25 mg/kg/day over the course of three days) and patients without additional vitamin E. Material and methods: A set of 100 neonatal indirect hyperbilirubinemia patients was enrolled at neonatal intensive care units (NICUs) of the pediatric departments at Al Azhar University Hospitals during the period from February 2021 to October 2022 after obtaining signed written informed consent of all neonates' parents with an explanation of the aim of study. Results: Significant differences were found between the studied groups regarding serum bilirubin on the third day of admission ( Conclusions: Vitamin E supplementation has an important role in treatment of indirect hyperbilirubinemia in neonates. Early administration of vitamin E in preterm neonates resulted in a significant decrease of serum bilirubin and increased total antioxidant capacity. Vitamin E supplementation in full term decreased the duration of phototherapy.

Indexed as

hyperbilirubinemianeonataloxidative stresstotal antioxidant capacityvitamin E

Identifiers

PMID38765909
PMCPMC11100342

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.