ArticleWorld journal of clinical cases2024
Different effects of 24 dietary intakes on gastroesophageal reflux disease: A mendelian randomization.
Article in World journal of clinical cases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Bidirectional and mediation Mendelian randomization of dietary intake and risks of gastric ulcer and gastric cancer.Medicine · 2026Article
- FODMAP intake, gut microbiota, and gastroesophageal reflux disease: a triangulated study of Mendelian randomization and clinical validation.Frontiers in nutrition · 2026Article
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Authors and funding
3 authors.
Funding
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Abstract
backgroundIn observational studies, dietary intakes are associated with gastroesophageal reflux disease (GERD).
aimTo conduct a two-sample mendelian randomization (MR) analysis to determine whether those associations are causal.
methodsTo explore the relationship between dietary intake and the risk of GERD, we extracted appropriate single nucleotide polymorphisms from genome-wide association study data on 24 dietary intakes. Three methods were adopted for data analysis: Inverse variance weighting, weighted median methods, and MR-Egger's method. The odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the causal association between dietary intake and GERD.
resultsOur univariate Mendelian randomization (UVMR) results showed significant evidence that pork intake (OR, 2.83; 95%CI: 1.76-4.55;
conclusionThis study provides MR evidence to support the causal relationship between a broad range of dietary intake and GERD, providing new insights for the treatment and prevention of GERD.
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