Evidence map›Paper›PMID 38765701›Full record

ArticleFrontiers in sleep2024

Serotonin transporter density in isolated rapid eye movement sleep behavioral disorder.

Mark Garwood, Punithavathy Vijayakumar, Nicolaas I Bohnen, Robert A Koeppe, Vikas Kotagal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in sleep, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Increased frontal [NPJ Parkinson's disease · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mark GarwoodDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States.
Punithavathy VijayakumarDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States.
Nicolaas I BohnenDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States.
Robert A KoeppeDivision of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, MI, United States.
Vikas KotagalDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States.

Funding

Tomography and Data AnalysisP01NS015655 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FREY, KIRK A. · 1985 to 2012
$13.0M
Udall Catalyst Research Project: Retrosplenial Cholinergic and Attentional-Motor Integration DysfunctionP50NS123067 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AHMED, OMAR JAMIL · 2021 to 2025
$11.6M
Neurobiological drivers of mobility resilience: the dopaminergic systemU01AG061393 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BOHNEN, NICOLAAS IDA, ROSANO, CATERINA · 2018 to 2022
$6.2M
Citalopram as a posterior cortical protective therapy in Parkinson diseaseR01AG065246 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOTAGAL, VIKAS · 2020 to 2024
$3.3M
Central cholinergic presbyvestibulopathy network changes and imbalance in Parkinson's disease and older personsR01AG073100 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2021 to 2025
$3.0M
Early Serotonin System Changes in prodromal DLBR56AG065529 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOTAGAL, VIKAS · 2020 to 2020
$692k
White Matter Lesions and Cortical Serotonergic Deafferentation in Older AdultsR03AG034338 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MULLER, MARTIJN L. T. M. · 2009 to 2010
$127k
Amyloidopathy, cholinopathy, dopamine responsiveness and freezing of gait in PDI01RX001631 · VA · VETERANS HEALTH ADMINISTRATION · PI BOHNEN, NICOLAAS IDA · 2016 to 2020
–
NIA NIH HHS R01 AG065246NIA NIH HHS R01 AG073100NIA NIH HHS R03 AG034338NIA NIH HHS R56 AG065529NIA NIH HHS U01 AG061393NINDS NIH HHS P01 NS015655NINDS NIH HHS P50 NS123067RRD VA I01 RX001631
6 · The paper itself

Abstract

Background/objective: The serotoninergic nervous system is known to play a role in the maintenance of rapid eye movement (REM) sleep. Serotoninergic projections are known to be vulnerable in synucleinopathies. To date, positron emission tomography (PET) studies using serotonin-specific tracers have not been reported in isolated REM sleep behavior disorder (iRBD). Methods: We conducted a cross-sectional imaging study using serotonin transporter (SERT) Results: Participants with iRBD showed lower DASB distribution volume ratios (DVRs) in the total neocortical mantle [1.13 (SD: 0.07) vs. 1.19 (SD: 0.06); Conclusions: Insular, neocortical, and striatal serotoninergic terminal loss may be common in prodromal synucleinopathies before the onset of parkinsonism or dementia. Given our small sample size, these results should be interpreted as hypothesis-generating/exploratory in nature.

Indexed as

DASBPET imagingrapid eye movement sleep behavior disorderserotoninsleep

Identifiers

PMID38765701
PMCPMC11101191

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.