Evidence map›Paper›PMID 38765576›Full record

ArticleKidney international reports2024

Effect of Sustained Clinical Remission on the Risk of Lupus Flares and Impaired Kidney Function in Patients With Lupus Nephritis.

Mariele Gatto, Giulia Frontini, Marta Calatroni, Francesco Reggiani, Roberto Depascale, Claudio Cruciani, Silvana Quaglini, Lucia Sacchi, Barbara Trezzi, Grazia Dea Bonelli and 8 more

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In one paragraph

Article in Kidney international reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  8. Observational
  9. Article
  10. Article
  11. Not So Benign: Revisiting Pure Membranous Lupus Nephritis.Journal of personalized medicine · 2025
    Review
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  13. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Mariele GattoAcademic Rheumatology Centre, Department of Clinical and Biological Sciences, University of Turin, Mauriziano Hospital, Turin, Italy.
Giulia FrontiniNephrology and Dialysis Unit, San Paolo Hospital, Milan, Italy.
Marta CalatroniNephrology and Dialysis Division, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Francesco ReggianiNephrology and Dialysis Division, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Roberto DepascaleRheumatology Unit, Department of Medicine, University of Padua, Italy.
Claudio CrucianiRheumatology Unit, Department of Medicine, University of Padua, Italy.
Silvana QuagliniDepartment of Electrical, Computer and Biomedical Engineering, University of Pavia, Italy.
Lucia SacchiDepartment of Electrical, Computer and Biomedical Engineering, University of Pavia, Italy.
Barbara TrezziDepartment of Medicine and Surgery, University Milano Bicocca, Milan, Italy.
Grazia Dea BonelliDepartment of Medicine and Surgery, University Milano Bicocca, Milan, Italy.
Vincenzo L'ImperioDepartment of Medicine and Surgery, Pathology, University Milano-Bicocca, IRCCS Fondazione San Gerardo dei Tintori, Monza, Italy.
Augusto VaglioNephrology and Dialysis Unit, Meyer Children's University Hospital, Florence, Italy.
Claudia FurlanDepartment of Statistical Sciences, University of Padova, Padova, Italy.
Margherita ZenRheumatology Unit, Department of Medicine, University of Padua, Italy.
Luca IaccarinoRheumatology Unit, Department of Medicine, University of Padua, Italy.
Renato Alberto SinicoNephrology and Dialysis Division, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Andrea DoriaRheumatology Unit, Department of Medicine, University of Padua, Italy.
Gabriella MoroniNephrology and Dialysis Division, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This retrospective study on patients with biopsy-proven lupus nephritis (LN) aimed to assess the probability of sustained clinical remission (sCR) and to investigate sCR effects on disease flares and impaired kidney function (IKF). Methods: sCR was defined as clinical-Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) = 0 and estimated glomerular filtration rate (eGFR) >60 ml/min per 1.73 m Results: Of 303 patients followed-up with for 14.8 (interquartile range: 9.8-22) years, 257 (84.8%) achieved sCR. The probability of achieving sCR progressively increased over time reaching 90% at 15 years. Baseline age (hazard ratio [HR]: 1.017; 95% confidence interval [CI]: 0.005-1.029; Conclusion: sCR is an achievable target in LN management and protects against IKF. The longer the sCR, the higher the chance of its persistence and the lower the risk of SLE flares.

Indexed as

impaired kidney functionlupus flareslupus nephritisremissionsustained clinical remission

Identifiers

PMID38765576
PMCPMC11101726

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.