Evidence map›Paper›PMID 38765561›Full record

ArticleKidney international reports2024

Calciphylaxis Episodes in the Australia and New Zealand Dialysis and Transplant Registry.

Nigel D Toussaint, Christopher E Davies, Elisa Bongetti, Irene Ruderman, Grahame J Elder, Carmel M Hawley, Rathika Krishnasamy, Matthew A Roberts, Meg J Jardine, Janak R De Zoysa and 1 more

Abstract read
In one paragraph

Article in Kidney international reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nigel D ToussaintDepartment of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.
Christopher E DaviesFaculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.
Elisa BongettiDepartment of Nephrology, Monash Medical Centre, Clayton, Australia.
Irene RudermanDepartment of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.
Grahame J ElderSchool of Medicine, University of Notre Dame, Sydney, Australia.
Carmel M HawleyDepartment of Nephrology, Princess Alexandra Hospital, Brisbane, Australia.
Rathika KrishnasamyDepartment of Nephrology, Sunshine Coast Hospital University Hospital, Birtinya, Australia.
Matthew A RobertsEastern Health Clinical School, Monash University, Box Hill, Australia.
Meg J JardineNHMRC Clinical Trials Centre, University of Sydney New South Wales, Australia.
Janak R De ZoysaFaculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand.
Stephen P McDonaldFaculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Calciphylaxis is a rare disorder associated with significant morbidity and mortality. Data registries are an invaluable source of information for rare diseases. We reviewed cases of calciphylaxis recorded in the Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) and evaluated associations and outcomes of this condition. Methods: Data was obtained on all cases of calciphylaxis reported between 2019 and 2022 in Australian and New Zealand patients on kidney replacement therapy (KRT). This cohort was compared to all patients in the registry who received KRT from 2019 to 2022 without an episode of calciphylaxis. Cox proportional hazards regression including a time-varying covariate for calciphylaxis episode was conducted for mortality with models restricted to patients on dialysis only. Results: From 2019 to 2022, 333 patients had calciphylaxis episodes reported. Overall incidence rate for patients on dialysis was 4.5 (4.1-5.1) episodes per 1000 patient-years on dialysis. Median age was 63 (interquartile range [IQR]: 55-73) years, 54% were female, 66% had diabetes, 59% were obese (body mass index [BMI] ≥ 30 kg/m Conclusion: Calciphylaxis is a rare but life-threatening condition in people on KRT with the greatest mortality burden within 12 months of diagnosis.

Indexed as

calciphylaxisdialysiskidney failurekidney replacement therapymineral metabolismregistry

Identifiers

PMID38765561
PMCPMC11101771

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.