Evidence map›Paper›PMID 38765246›Full record

ReviewMaterials today. Bio2024

Engineering antibacterial bioceramics: Design principles and mechanisms of action.

Ngoc Huu Nguyen, Zufu Lu, Aaron Elbourne, Krasimir Vasilev, Iman Roohani, Hala Zreiqat, Vi Khanh Truong

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials today. Bio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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  13. ZnInternational journal of molecular sciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ngoc Huu NguyenSchool of Biomedical Engineering, The University of Sydney, Camperdown, NSW, 2006, Australia.
Zufu LuSchool of Biomedical Engineering, The University of Sydney, Camperdown, NSW, 2006, Australia.
Aaron ElbourneSchool of Science, RMIT University, Melbourne, Victoria, 3001, Australia.
Krasimir VasilevBiomedical Nanoengineering Laboratory, College of Medicine and Public Health, Flinders University, Bedford Park SA 5042, Australia.
Iman RoohaniSchool of Biomedical Engineering, The University of Sydney, Camperdown, NSW, 2006, Australia.
Hala ZreiqatSchool of Biomedical Engineering, The University of Sydney, Camperdown, NSW, 2006, Australia.
Vi Khanh TruongBiomedical Nanoengineering Laboratory, College of Medicine and Public Health, Flinders University, Bedford Park SA 5042, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The urgency to address skeletal abnormalities and diseases through innovative approaches has led to a significant interdisciplinary convergence of engineering, 3D printing, and design in developing individualised bioceramic bioscaffolds. This review explores into the recent advancements and future trajectory of non-antibiotic antibacterial bioceramics in bone tissue engineering, an importance given the escalating challenges of orthopaedic infections, antibiotic resistance, and emergent pathogens. Initially, the review provides an in-depth exploration of the complex interactions among bacteria, immune cells, and bioceramics in clinical contexts, highlighting the multifaceted nature of infection dynamics, including protein adsorption, immunological responses, bacterial adherence, and endotoxin release. Then, focus on the next-generation bioceramics designed to offer multifunctionality, especially in delivering antibacterial properties independent of traditional antibiotics. A key highlight of this study is the exploration of smart antibacterial bioceramics, marking a revolutionary stride in medical implant technology. The review also aims to guide the ongoing development and clinical adoption of bioceramic materials, focusing on their dual capabilities in promoting bone regeneration and exhibiting antibacterial properties. These next-generation bioceramics represent a paradigm shift in medical implant technology, offering multifunctional benefits that transcend traditional approaches.

Indexed as

AntimicrobialBioceramicsImplant-associated infectionOrthopaedic implant

Identifiers

PMID38765246
PMCPMC11099329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.