Evidence map›Paper›PMID 38765190›Full record

ArticleRheumatology advances in practice2024

BASDAI versus ASDAS in evaluating axial involvement in patients with psoriatic arthritis: a pooled analysis of two phase 3 studies.

Xenofon Baraliakos, Dafna D Gladman, Soumya D Chakravarty, Cinty Gong, May Shawi, Emmanouil Rampakakis, Mitsumasa Kishimoto, Enrique R Soriano, Philip J Mease

2 registry-linked trialsAbstract read
In one paragraph

Article in Rheumatology advances in practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03158285 phase3completednot on this map

A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Guselkumab Administered Subcutaneously in Subjects With Active Psoriatic Arthritis

TypeinterventionalSponsorJanssen Research & Development, LLCRan2017 to 2020Enrolled741ConditionsArthritis, PsoriaticArmsGuselkumab, Placebo
NCT03162796 phase3completednot on this map

A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Guselkumab Administered Subcutaneously in Subjects With Active Psoriatic Arthritis Including Those Previously Treated With Biologic Anti-TNF Alpha Agents

TypeinterventionalSponsorJanssen Research & Development, LLCRan2017 to 2019Enrolled383ConditionsArthritis, PsoriaticArmsGuselkumab, Placebo
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xenofon BaraliakosRheumazentrum Ruhrgebiet, Ruhr-University Bochum, Herne, Germany.ORCID https://orcid.org/0000-0002-9475-9362
Dafna D GladmanDepartment of Medicine, University of Toronto, Schroeder Arthritis Institute; Krembil, Research Institute; Toronto Western Hospital, Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-9074-0592
Soumya D ChakravartyImmunology, Janssen Scientific Affairs, LLC, a Johnson & Johnson company, Horsham, PA, USA.ORCID https://orcid.org/0000-0001-7957-838X
Cinty GongImmunology, Janssen Research & Development, LLC, a Johnson & Johnson company, Spring House, PA, USA.ORCID https://orcid.org/0000-0003-1158-0699
May ShawiImmunology, Janssen Research & Development, LLC, a Johnson & Johnson company, Titusville, NJ, USA.ORCID https://orcid.org/0000-0001-6005-3938
Emmanouil RampakakisDepartment of Pediatrics, McGill University, Montreal, Canada.
Mitsumasa KishimotoDepartment of Nephrology and Rheumatology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.ORCID https://orcid.org/0000-0002-4007-1589
Enrique R SorianoRheumatology Section, Internal Medicine Service, Department of Medicine, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.ORCID https://orcid.org/0000-0003-3143-1084
Philip J MeaseRheumatology Research, Providence Swedish Medical Center, Seattle, WA, USA.ORCID https://orcid.org/0000-0002-6620-0457

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: In the absence of axial psoriatic arthritis (axPsA)-specific tools, the BASDAI and Ankylosing Spondylitis Disease Activity Score (ASDAS) are used to assess axial symptoms in patients with PsA. Here, we assessed the performance of BASDAI and ASDAS in patients with PsA. Methods: Patients with active PsA in DISCOVER-1 and DISCOVER-2 (ClinicalTrials.gov: NCT03162796 and NCT03158285, respectively) with or without axPsA but with available baseline BASDAI information were analysed; those with investigator-identified axial symptoms and imaging-confirmed sacroiliitis comprised the axPsA cohort. Correlations between BASDAI/ASDAS and clinical variables were assessed with Pearson's coefficient ( Results: At baseline in the axPsA ( Conclusion: BASDAI and ASDAS performed similarly in patients with active PsA and axial involvement, independent of peripheral disease involvement, supporting their performance in assessing axial disease activity. Trial registration: ClinicalTrials.gov, http://clinicaltrials.gov, NCT03162796 and NCT03158285.

Indexed as

ASDASBASDAIclinical trialsdiagnostic imagingMRIpsoriatic arthritisspinespondyloarthropathies

Identifiers

PMID38765190
PMCPMC11099656

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.