Evidence map›Paper›PMID 38765185›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering2024

Adapting SAM to Histopathology Images for Tumor Bud Segmentation in Colorectal Cancer.

Ziyu Su, Wei Chen, Sony Annem, Usama Sajjad, Mostafa Rezapour, Wendy L Frankel, Metin N Gurcan, M Khalid Khan Niazi

Abstract read
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ziyu SuCenter for Artificial Intelligence Research, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Wei ChenDepartment of Pathology, The Ohio State University, Columbus, OH, USA.
Sony AnnemDepartment of Computer Science, The University of North Carolina at Greensboro, Greensboro, NC, USA.
Usama SajjadCenter for Artificial Intelligence Research, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Mostafa RezapourCenter for Artificial Intelligence Research, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Wendy L FrankelDepartment of Pathology, The Ohio State University, Columbus, OH, USA.
Metin N GurcanCenter for Artificial Intelligence Research, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
M Khalid Khan NiaziCenter for Artificial Intelligence Research, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Funding

Computer-assisted diagnosis of ear pathologies by combining digital otoscopy with complementary data using machine learningR01DC020715 · NIDCD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Metin Nafi Gurcan, Aaron C Moberly · 2023 to 2026
$2.5M
An ensemble deep learning model for tumor bud detection and risk stratification in colorectal carcinoma.R01CA276301 · NCI · OHIO STATE UNIVERSITY · PI Wei Chen, Muhammad Khalid Khan Niazi · 2023 to 2026
$2.0M
Development of quantitative tools to predict patients with difficult intubation to minimize treatment related complicationsR21EB029493 · NIBIB · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI NIAZI, MUHAMMAD KHALID KHAN, SEGAL, SCOTT · 2021 to 2023
$620k
Efficient and cost-effective breast cancer risk stratification using whole slide histopathology imagesR21CA273665 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GURCAN, METIN NAFI · 2023 to 2024
$394k
NCI NIH HHS R01 CA276301NCI NIH HHS R21 CA273665NIBIB NIH HHS R21 EB029493NIDCD NIH HHS R01 DC020715
6 · The paper itself

Abstract

Colorectal cancer (CRC) is the third most common cancer in the United States. Tumor Budding (TB) detection and quantification are crucial yet labor-intensive steps in determining the CRC stage through the analysis of histopathology images. To help with this process, we adapt the Segment Anything Model (SAM) on the CRC histopathology images to segment TBs using SAM-Adapter. In this approach, we automatically take task-specific prompts from CRC images and train the SAM model in a parameter-efficient way. We compare the predictions of our model with the predictions from a trained-from-scratch model using the annotations from a pathologist. As a result, our model achieves an intersection over union (IoU) of 0.65 and an instance-level Dice score of 0.75, which are promising in matching the pathologist's TB annotation. We believe our study offers a novel solution to identify TBs on H&E-stained histopathology images. Our study also demonstrates the value of adapting the foundation model for pathology image segmentation tasks.

Indexed as

attention mechanismColorectal cancercross-attention networkdeep learninghistopathology imagesmultiple instance learningtumor buddingweakly supervised learning

Identifiers

PMID38765185
PMCPMC11099868

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.