ArticlePsychiatry and clinical psychopharmacology2022
Comparison of Clinical Features, Serum Lipid, and Uric Acid Levels in Patients with Unipolar Depression and Bipolar Depression.
Article in Psychiatry and clinical psychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Peripheral biochemical parameters for discrimination between bipolar disorder and major depressive disorder in female patients of reproductive age: a CRP-stratified exploratory study.BMC psychiatry · 2026Article
- Relationship between uric acid and depression in American adults: findings from NHANES, 2005-2020.Frontiers in psychiatry · 2025Article
- Exploring the relationship between the uric acid to high-density lipoprotein cholesterol ratio and depression: a cross-sectional study from NHANES.Scientific reports · 2024Article
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Authors and funding
5 authors.
Funding
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Abstract
Background: The level of uric acid and serum lipids has been suggested as a possible biomarker of bipolar disorder. We aimed to investigate the differences in clinical features and serum levels of lipids and uric acid in patients with bipolar depression or unipolar depression in order to distinguish them. Methods: The clinical data of 53 patients with unipolar depression (unipolar group) and 61 patients with bipolar depression (bipolar group), who all met the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders-IV of the American Psychiatric Association, were compared with each other retrospectively. The serum levels of uric acid and lipids (including total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides) were measured after hospital admission. The Statistical Package for the Social Science version 22.0 software was used for statistical analysis, and logistic regression was employed to identify the susceptible factors of bipolar depression. Results: Taking into account confounding factors, logistic regression analysis revealed that the high levels of uric acid (odds ratio = 1.016, Conclusion: It has been demonstrated from this study that individuals with bipolar depression have higher serum uric acid levels and lower triglyceride levels than unipolar depression ones. Therefore, serum levels of uric acid and triglycerides might have the potential to be the biomarkers for differential diagnosis between bipolar and unipolar depression.
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