ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Sleep functional connectivity, hyperexcitability, and cognition in Alzheimer's disease.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Alzheimer's Disease Detection Using Combined EEG Source Connectivity and Microstate Features.Brain sciences · 2026Article
- Association of Sleep Spindle Activity With Cognitive Decline in Early Clinical Stages of Alzheimer Disease.Neurology · 2026Article
- Sleep electroencephalography-derived brain health and long-term cognitive decline in community-dwelling adults.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Light-based 40 Hz sensory therapy for brain disorders: physiological basis, therapeutic mechanisms, and future prospects.Frontiers in medicine · 2026Review
- Circadian Rhythms in Aging and Age-Related Neurogenerative Disease.Current sleep medicine reports · 2025Article
- Imbalance, compensation, and rigidity in brain functional connectivity and microstates among older adults with cognitive impairment.Journal of neuroengineering and rehabilitation · 2025Article
- Phase precession of spindle-slow oscillation coupling across the human brain.bioRxiv : the preprint server for biology · 2025Article
- Partial normalization of hippocampal oscillatory activity during sleep in TgF344-AD rats coincides with increased cholinergic synapses at early-plaque stage of Alzheimer's disease.Acta neuropathologica communications · 2025Article
- Plasma biomarkers as core mediators in functional network abnormalities: Evidence from a two-cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Microglial TREM2 and cognitive impairment: insights from Alzheimer's disease with implications for spinal cord injury and AI-assisted therapeutics.Frontiers in cellular neuroscience · 2025Review
- Sleep functional connectivity, hyperexcitability, and cognition in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
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Authors and funding
8 authors.
Funding
Abstract
introductionSleep disturbances are common in Alzheimer's disease (AD) and may reflect pathologic changes in brain networks. To date, no studies have examined changes in sleep functional connectivity (FC) in AD or their relationship with network hyperexcitability and cognition.
methodsWe assessed electroencephalogram (EEG) sleep FC in 33 healthy controls, 36 individuals with AD without epilepsy, and 14 individuals with AD and epilepsy.
resultsAD participants showed increased gamma connectivity in stage 2 sleep (N2), which was associated with longitudinal cognitive decline. Network hyperexcitability in AD was associated with a distinct sleep connectivity signature, characterized by decreased N2 delta connectivity and reversal of several connectivity changes associated with AD. Machine learning algorithms using sleep connectivity features accurately distinguished diagnostic groups and identified "fast cognitive decliners" among study participants who had AD. DISCUSSION: Our findings reveal changes in sleep functional networks associated with cognitive decline in AD and may have implications for disease monitoring and therapeutic development. HIGHLIGHTS: Brain functional connectivity (FC) in Alzheimer's disease is altered during sleep. Sleep FC measures correlate with cognitive decline in AD. Network hyperexcitability in AD has a distinct sleep connectivity signature.
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