Evidence map›Paper›PMID 38764247›Full record

SynthesisPsychology & health2025

Personality traits and polypharmacy: meta-analysis of five samples.

Yannick Stephan, Angelina R Sutin, Antonio Terracciano

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Psychology & health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Personality and falls: evidence from three samples.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yannick StephanEuromov, University of Montpellier, Montpellier, France.ORCID 0000-0002-8029-8809
Angelina R SutinDepartment of Behavioral Sciences and Social Medicine, College of Medicine, Florida State University, Tallahassee, USA.ORCID 0000-0002-1824-8974
Antonio TerraccianoDepartment of Geriatrics, College of Medicine, Florida State University, Tallahassee, USA.ORCID 0000-0001-5799-8885

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
U19 MIDlife in the United States-Diversity Supplement-WellsU19AG051426 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAROL D. RYFF · 2016 to 2026
$74.8M
Project-001R01AG017644 · NIA · UNIVERSITY OF LONDON INST OF NEUROLOGY · PI Andrew Steptoe · 2000 to 2026
$56.2M
STATISTICS COREP01AG020166 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI RYFF, CAROL D. · 2002 to 2015
$50.6M
ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
WISCONSIN LONGITUDINAL STUDY--SIBLING INTERVIEWS (1)R01AG009775 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI HERD, PAMELA · 1991 to 2012
$23.4M
WORK, HEALTH, AND WELL-BEINGP01AG021079 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI PALLONI, ALBERTO B. · 2002 to 2011
$14.2M
Aging Together: Brothers and Sisters of the Wisconsin Longitudinal StudyR01AG033285 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI HERD, PAMELA, WARREN, JOHN ROBERT · 2009 to 2013
$11.8M
WIHS INTENSIVE PHARMACOKINETIC STUDY (IPS)M01RR023942 · NCRR · GEORGETOWN UNIVERSITY · PI FEDEROFF, HOWARD J. · 2007 to 2009
$6.9M
A Longitudinal Resource for Genetic Research in Behavioral & Health SciencesR01AG041868 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI FREESE, JEREMY J, HAUSER, ROBERT M. · 2013 to 2017
$3.0M
NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1 TR002373NCRR NIH HHS M01 RR000865NCRR NIH HHS M01 RR023942NIA NIH HHS P01 AG020166NIA NIH HHS P01 AG021079NIA NIH HHS R01 AG009775NIA NIH HHS R01 AG017644NIA NIH HHS R01 AG033285NIA NIH HHS R01 AG041868NIA NIH HHS R01 AG068093NIA NIH HHS U01 AG009740NIA NIH HHS U19 AG051426
6 · The paper itself

Abstract

objectiveThe present study examined the prospective relationship between personality traits and the risk of polypharmacy. METHODS AND MEASURES: Participants (age range: 16-101 years;

resultsRandom-effect meta-analyses revealed that higher neuroticism was related to a higher risk of polypharmacy (Odd Ratio = 1.30; 95% CI 1.17-1.46) and excessive polypharmacy (Odd Ratio = 1.44; 95% CI 1.18-1.77) whereas higher conscientiousness (Odd Ratio = 0.84; 95% CI 0.74-0.95) and extraversion (Odd Ratio = 0.85; 95% CI 0.73-0.98) were associated with a lower risk of polypharmacy. Openness and agreeableness were unrelated to polypharmacy. Body mass index, number of chronic conditions, and depressive symptoms partially mediated the association between personality and the number of medications.

conclusionThe present study provides replicable and robust evidence that neuroticism is a risk factor for simultaneous use of multiple medications, whereas conscientiousness and extraversion may play a protective role.

Indexed as

PersonalityPolypharmacyAdolescentAdultAgedAged, 80 and overFemaleHumansLongitudinal StudiesMaleMiddle AgedNeuroticismUnited StatesYoung AdulthealthPersonalitypolypharmacy

Identifiers

PMID38764247
PMCPMC11573927

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.