Evidence map›Paper›PMID 38764181›Full record

ArticleObesity (Silver Spring, Md.)2024

Deficits in brain glucose transport among younger adults with obesity.

Felona Gunawan, Brooke C Matson, Anastasia Coppoli, Lihong Jiang, Yuyan Ding, Rachel Perry, Elizabeth Sanchez-Rangel, Renata Belfort DeAguiar, Kevin L Behar, Douglas L Rothman and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Feasibility of ConcurrentNMR in biomedicine · 2026
    Article
  2. Review
  3. Impact of obesity on aromatic amino acids and brain glucose during acute hyperglycemia.American journal of physiology. Endocrinology and metabolism · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Felona GunawanSection of Endocrinology and Metabolism, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.
Brooke C MatsonDivision of Endocrinology and Metabolism, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.ORCID 0000-0003-1979-1562
Anastasia CoppoliYale Magnetic Resonance Research Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.
Lihong JiangYale Magnetic Resonance Research Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.
Yuyan DingSection of Endocrinology and Metabolism, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.
Rachel PerrySection of Endocrinology and Metabolism, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.ORCID 0000-0003-0748-8064
Elizabeth Sanchez-RangelSection of Endocrinology and Metabolism, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.
Renata Belfort DeAguiarSection of Endocrinology and Metabolism, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.
Kevin L BeharYale Magnetic Resonance Research Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.
Douglas L RothmanYale Magnetic Resonance Research Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.
Graeme F MasonYale Magnetic Resonance Research Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.
Janice J HwangSection of Endocrinology and Metabolism, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.

Funding

Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI GERALD I SHULMAN · 1993 to 2026
$44.0M
Institutional Career Development CoreKL2TR001862 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$12.2M
The impact of obesity on cerebral glucose transport and metabolismR01DK123227 · NIDDK · YALE UNIVERSITY · PI HWANG, JANICE JIN · 2020 to 2024
$2.5M
13C MRS Studies of Brain Mitochondrial Metabolism in Insulin ResistanceR01NS087568 · NINDS · YALE UNIVERSITY · PI PETERSEN, KITT F, ROTHMAN, DOUGLAS LYLE · 2014 to 2018
$2.1M
Comprehensive, Cross Platform-Validated 13C Flux Measures of Intra-and Inter-tissue MetabolismR01DK108283 · NIDDK · YALE UNIVERSITY · PI KIBBEY, RICHARD G, MASON, GRAEME F. · 2016 to 2019
$2.1M
Metabolic and neuromodulatory basis of altered activated and deactivated cortical areas in healthy human agingR56AG079086 · NIA · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED, ROTHMAN, DOUGLAS LYLE · 2022 to 2022
$657k
Investigating the impact of APOE on cerebral energeticsR21AG073897 · NIA · YALE UNIVERSITY · PI HWANG, JANICE JIN · 2021 to 2022
$446k
Relationship of Brain Ethanol Oxidation with BehaviorR21AA028628 · NIAAA · YALE UNIVERSITY · PI MASON, GRAEME F. · 2020 to 2021
$440k
The impact of obesity on cerebral energeticsR03DK121048 · NIDDK · YALE UNIVERSITY · PI HWANG, JANICE JIN · 2019 to 2020
$168k
Endocrine Fellows FoundationNCATS NIH HHS KL2 TR001862NIAAA NIH HHS R21 AA028628NIA NIH HHS R21 AG073897NIA NIH HHS R56 AG079086NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK108283NIDDK NIH HHS R01 DK123227NIDDK NIH HHS R03 DK121048NIH HHS AA028628NIH HHS AG073897NIH HHS AG079086NIH HHS DK045735NIH HHS DK108283NIH HHS DK121048NIH HHS DK123227NIH HHS NS087568NIH HHS TR001862NINDS NIH HHS R01 NS087568
6 · The paper itself

Abstract

objectiveObesity is associated with alterations in eating behavior and neurocognitive function. In this study, we investigate the effect of obesity on brain energy utilization, including brain glucose transport and metabolism.

methodsA total of 11 lean participants and 7 young healthy participants with obesity (mean age, 27 years) underwent magnetic resonance spectroscopy scanning coupled with a hyperglycemic clamp (target, ~180 mg/dL) using [1-

resultsIndividuals with obesity demonstrated an ~20% lower ratio of brain glucose uptake to cerebral glucose metabolic rate (T

conclusionsWe conclude that CMR

Indexed as

BrainGlucoseInsulin ResistanceObesityAdultBiological TransportBlood GlucoseCitric Acid CycleEnergy MetabolismFatty Acids, NonesterifiedFemaleGlucose Clamp TechniqueHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleBlood GlucoseFatty Acids, NonesterifiedGlucose

Identifiers

PMID38764181
PMCPMC11966602

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.