Evidence map›Paper›PMID 38763972›Full record

ArticleBreast cancer research and treatment2024

Development and application of a weighted change score to evaluate interventions for vasomotor symptoms in patients with breast cancer using regression trees: a cohort study.

Katherine Marie Cole, Sharon McGee, Mark Clemons, Michelle Liu, Fiona MacDonald, Lisa Vandermeer, Terry L Ng, Gregory Pond, Khaled El Emam

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research and treatment, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05222464 (Utilizing MyChart to Assess the Effectiveness of Interventions for Vasomotor Symptoms), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05222464 phase4completednot on this map

Utilizing MyChart to Assess the Effectiveness of Interventions for Vasomotor Symptoms: A Feasibility Study (REaCT-Hot Flashes Pilot)

TypeinterventionalSponsorOttawa Hospital Research InstituteRan2022 to 2022Enrolled56ConditionsBreast CancerArmsStandard of care treatments
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Katherine Marie ColeDepartment of Medicine, Division of Medical Oncology, University of Ottawa, Ottawa, ON, Canada.
Sharon McGeeDepartment of Medicine, Division of Medical Oncology, University of Ottawa, Ottawa, ON, Canada.
Mark ClemonsDepartment of Medicine, Division of Medical Oncology, University of Ottawa, Ottawa, ON, Canada.
Michelle LiuCancer Therapeutics Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Fiona MacDonaldThe Ottawa Hospital Cancer Centre, Ottawa, ON, Canada.
Lisa VandermeerCancer Therapeutics Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Terry L NgDepartment of Medicine, Division of Medical Oncology, University of Ottawa, Ottawa, ON, Canada.
Gregory PondDepartment of Oncology, McMaster University, Hamilton, ON, Canada.
Khaled El EmamSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada. kelemam@ehealthinformation.ca.

Funding

Discovery Grant -Natural Sciences and Engineering Research Council of Canada RGPIN-2022-04811
6 · The paper itself

Abstract

purposeVasomotor symptoms (VMS) are common among individuals with breast cancer (BC) and poorly managed symptoms are associated with reduced quality of life, treatment discontinuation, and poorer breast cancer outcomes. Direct comparisons among therapies are limited, as prior studies evaluating VMS interventions have utilized heterogeneous change measures which may not fully assess the perceived impact of change in VMS severity.

methodsWe performed a prospective study where BC patients chose one of four categories of interventions to manage VMS. Change in VMS severity at 6 weeks was assessed using the validated Hot Flush Rating Scale (HFRS). A novel weighted change score integrating baseline symptom severity and directionality of change was computed to maximize the correlation between the change score and a perceived treatment effectiveness score. Variables influencing change in VMS severity were included in a regression tree to model factors influencing the weighted change score.

results100 baseline and follow-up questionnaires assessing VMS were completed by 88 patients. Correlations between treatment effectiveness and VMS outcomes strengthened following adjustment for baseline symptoms. Patients with low VMS severity at baseline did not perceive change in treatment effectiveness. Intervention category was predictive of change in HFRS at 6 weeks.

conclusionBaseline symptom severity and the directionality of change (improvement or deterioration of symptoms) influenced the perception of clinically meaningful change in VMS severity. Future interventional studies utilizing the weighted change score should target moderate-high baseline severity patients.

Indexed as

Breast NeoplasmsHot FlashesQuality of LifeAdultAgedFemaleHumansMiddle AgedProspective StudiesSeverity of Illness IndexSurveys and QuestionnairesTreatment OutcomeVasomotor SystemBreast cancerHot flashesMachine learningRegression treesVasomotor symptoms

Identifiers

PMID38763972
PMCPMC11297085

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.