Evidence map›Paper›PMID 38763956›Full record

ArticleCellular and molecular life sciences : CMLS2024

Transcriptomic profiling and regulatory pathways of cardiac resident macrophages in aging.

Guofang Xia, Simeng Zhu, Yujia Liu, Jingwei Pan, Xiaoqing Wang, Chengxing Shen, Ailian Du, Congfeng Xu

Abstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Differential transcriptomic profiling of lipid metabolism and collagen remodeling in fast- and slow-twitch skeletal muscles in aging.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guofang Xia *Department of Cardiology, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital, Shanghai, China.
Simeng Zhu *Department of Cardiology, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital, Shanghai, China.
Yujia LiuDepartment of Neurology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jingwei PanDepartment of Cardiology, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital, Shanghai, China.
Xiaoqing WangDepartment of Cardiology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital (SAMSPH), Chengdu, China.
Chengxing ShenDepartment of Cardiology, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital, Shanghai, China. shencx@sjtu.edu.cn.
Ailian DuDepartment of Neurology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 732002780@shsmu.edu.cn.
Congfeng XuDepartment of Cardiology, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital, Shanghai, China. cxu@shsmu.edu.cn.ORCID http://orcid.org/0000-0002-8009-4865

Funding

National Natural Science Foundation of China 31870885National Natural Science Foundation of China 82171812Scientific and Technological Innovation Action Plan of Science and Technology Commission of Shanghai Municipality 21Y11909400The Medical and Engineering Crossover Fund of SJTU YG2024ZD27
6 · The paper itself

Abstract

Cardiovascular diseases are an array of age-related disorders, and accumulating evidence suggests a link between cardiac resident macrophages (CRMs) and the age-related disorders. However, how does CRMs alter with aging remains elusive. In the present study, aged mice (20 months old) have been employed to check for their cardiac structural and functional alterations, and the changes in the proportion of CRM subsets as well, followed by sorting of CRMs, including C-C Motif Chemokine Receptor 2 (CCR2)

Indexed as

AgingGene Expression ProfilingMacrophagesMice, Inbred C57BLReceptors, CCR2AnimalsInflammationMaleMiceMyocardiumPhagocytosisSignal TransductionSingle-Cell AnalysisTranscriptomeCcr2 protein, mouseReceptors, CCR2AgingCardiac resident macrophagesMacrophagesSmart-SeqTranscriptomic profiling

Identifiers

PMID38763956
PMCPMC11102896

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.