Evidence map›Paper›PMID 38763889›Full record

ArticleBrain pathology (Zurich, Switzerland)2024

Decreased microvascular claudin-5 levels in cerebral amyloid angiopathy associated with intracerebral haemorrhage.

Lieke Jäkel, Kiki K W J Claassen, Anna M De Kort, Wilmar M T Jolink, Yannick Vermeiren, Floris H B M Schreuder, Benno Küsters, Catharina J M Klijn, H Bea Kuiperij, Marcel M Verbeek

Abstract read
In one paragraph

Article in Brain pathology (Zurich, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lieke JäkelDepartment of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Kiki K W J ClaassenDepartment of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Anna M De KortDepartment of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Wilmar M T JolinkDepartment of Neurology, Isala Hospital, Zwolle, The Netherlands.
Yannick VermeirenDivision of Human Nutrition and Health, Chair Group Nutritional Biology, Wageningen University & Research (WUR), Wageningen, The Netherlands.
Floris H B M SchreuderDepartment of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Benno KüstersDepartment of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
Catharina J M KlijnDepartment of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
H Bea KuiperijDepartment of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Marcel M VerbeekDepartment of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0003-4635-7876

Funding

Cerebral amyloid angiopathy fluid biomarkers evaluation (CAFE)R01NS104147 · NINDS · UNIVERSITY OF RHODE ISLAND · PI VAN NOSTRAND, WILLIAM E. · 2018 to 2022
$3.2M
Alzheimer Nederland WE.03-2022-17Brain Foundation Netherlands HA2015.01.06Dutch Heart Foundation 2019T060Dutch Heart Foundation CVON2015-01: CONTRASTFoundation for the National Institutes of Health 5R01NS104147-02Ministry of Economic Affairs LSHM17016NINDS NIH HHS R01 NS104147Parkinson NL P2-21-18Stichting Alkemade-Keuls, Maag-Lever-Darm-stichting WOO 2105The Galen and Hilary Weston Foundation NR170024ZonMw 733050822ZonMW-Dementia program 10510032120003ZonMW-Dementia program 10510032120006
6 · The paper itself

Abstract

Decreased microvascular levels of claudin-5 in the occipital and temporal lobe of patients with cerebral amyloid angiopathy are associated with intracerebral haemorrhage.

Indexed as

Cerebral Amyloid AngiopathyCerebral HemorrhageClaudin-5AgedAged, 80 and overFemaleHumansMaleMicrovesselsMiddle AgedTemporal LobeClaudin-5CLDN5 protein, humanblood–brain barriercerebral amyloid angiopathyClaudin‐5immunohistochemistryintracerebral haemorrhage

Identifiers

PMID38763889
PMCPMC11483184

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.