Observational studyOsteoarthritis and cartilage2024
Associations of pain sensitivity and conditioned pain modulation with physical activity: findings from the Multicenter Osteoarthritis Study (MOST).
Observational study in Osteoarthritis and cartilage, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- High-definition transcranial direct current stimulation enhances exercise-induced hypoalgesia in patients with chronic low back pain.iScience · 2026Article
- Greater endogenous pain facilitation is associated with lower spinal excitability and maximal knee extension strength deficits in athletes with patellar tendinopathy.European journal of applied physiology · 2026Article
- The Relationship Between Physical Activity and Pain, Pain-Related Cognitions, and Central Sensitization in Patients With Midportion Achilles Tendinopathy.Orthopaedic journal of sports medicine · 2026Article
- Exploring the bidirectional temporal association between daily knee pain and physical activity in people with knee osteoarthritis: An exploratory smartwatch study.Osteoarthritis and cartilage open · 2026Article
- Reference Values of Joint-Specific Pressure Pain Thresholds in Healthy Male Individuals: A Retrospective Study.European journal of pain (London, England) · 2025Article
- Relation of pain sensitization to knee loading during walking in people with knee osteoarthritis.Osteoarthritis and cartilage · 2025Article
- Exercise Habits and Preferences of Community-Dwelling Older Adults with Chronic Pain: An Exploratory Study.Healthcare (Basel, Switzerland) · 2025Article
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Authors and funding
15 authors.
Funding
Abstract
objectiveIndividuals with chronic pain due to knee osteoarthritis (OA) are insufficiently physically active, and alterations of facilitatory and inhibitory nociceptive signaling are common in this population. Our objective was to examine the association of these alterations in nociceptive signaling with objective accelerometer-based measures of physical activity in a large observational cohort.
designWe used data from the Multicenter Osteoarthritis Study. Measures of peripheral and central pain sensitivity included pressure pain threshold at the knee and mechanical temporal summation at the wrist, respectively. The presence of descending pain inhibition was assessed by conditioned pain modulation (CPM). Physical activity was quantitatively assessed over 7 days using a lower back-worn activity monitor. Summary metrics included steps/day, activity intensity, and sedentary time. Linear regression analyses were used to evaluate the association of pain sensitivity and the presence of descending pain inhibition with physical activity measures.
resultsData from 1873 participants was analyzed (55.9% female, age = 62.8 ± 10.0 years). People having greater peripheral and central sensitivity showed lower step counts. CPM was not significantly related to any of the physical activity measures, and none of the exposures were significantly related to sedentary time.
conclusionsIn this cohort, greater peripheral and central sensitivity were associated with reduced levels of objectively-assessed daily step counts. Further research may investigate ways to modify or treat heightened pain sensitivity as a means to increase physical activity in older adults with knee OA.
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